Please use this identifier to cite or link to this item: https://doi.org/10.1210/er.2016-1103
Title: Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis
Authors: Sinha, Rohit A 
Singh, Brijesh K 
Yen, Paul M 
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
NONALCOHOLIC FATTY LIVER
ENDOPLASMIC-RETICULUM STRESS
PANCREATIC BETA-CELLS
CHAPERONE-MEDIATED AUTOPHAGY
5'-AMP-ACTIVATED PROTEIN-KINASE
THYROID-HORMONE REGULATION
VITAMIN-D3 INDUCES AUTOPHAGY
DOWN-REGULATION CONTRIBUTES
ADIPOSE-TISSUE AUTOPHAGY
HEPATIC LIPID-METABOLISM
Issue Date: 1-Feb-2017
Publisher: ENDOCRINE SOC
Citation: Sinha, Rohit A, Singh, Brijesh K, Yen, Paul M (2017-02-01). Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis. ENDOCRINE REVIEWS 38 (1) : 69-102. ScholarBank@NUS Repository. https://doi.org/10.1210/er.2016-1103
Abstract: Autophagy is a cellular quality control and energy-providing process that is under strict control by intra- and extracellular stimuli. Recently, there has been an exponential increase in autophagy research and its implications for mammalian physiology. Autophagy deregulation is now being implicated in many human diseases, and its modulation has shown promising results in several preclinical studies. However, despite the initial discovery of autophagy as a hormone-regulated process by De Duve in the early 1960s, endocrine regulation of autophagy still remains poorly understood. In this review, we provide a critical summary of our present understanding of the basic mechanism of autophagy, its regulation by endocrine hormones, and its contribution to endocrine and metabolic homeostasis under physiological and pathological settings. Understanding the cross-regulation of hormones and autophagy on endocrine cell signaling and function will provide new insight into mammalian physiology as well as promote the development of new therapeutic strategies involving modulation of autophagy in endocrine and metabolic disorders.
Source Title: ENDOCRINE REVIEWS
URI: https://scholarbank.nus.edu.sg/handle/10635/226756
ISSN: 0163769X
19457189
DOI: 10.1210/er.2016-1103
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