Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mce.2017.02.018
Title: Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy
Authors: Singh, Brijesh Kumar 
Sinha, Rohit Anthony 
Ohba, Kenji 
Yen, Paul Michael 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Endocrinology & Metabolism
Thyroid hormone
Gene transcription
microRNA (miRNA)
SIRT1
Forkhead box protein O1 (FOXO1)
Estrogen related receptor alpha (ESRRA/ERR alpha)
Autophagy
Mitophagy
Lipophagy
Aggerophagy
NONALCOHOLIC FATTY LIVER
NEGATIVE REGULATION
LIPID-METABOLISM
HISTONE MODIFICATIONS
BINDING-SITES
RECEPTOR-BETA
CO-REPRESSOR
TARGET GENES
SIRTUIN 1
TR-BETA
Issue Date: 15-Dec-2017
Publisher: ELSEVIER IRELAND LTD
Citation: Singh, Brijesh Kumar, Sinha, Rohit Anthony, Ohba, Kenji, Yen, Paul Michael (2017-12-15). Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy. MOLECULAR AND CELLULAR ENDOCRINOLOGY 458 (C) : 160-168. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mce.2017.02.018
Abstract: Thyroid hormone (TH) actions on development and metabolism have been studied ever since the discovery of thyroxine almost a century ago. Initial studies focused on the physiological and biochemical actions of TH. Later, the cloning of the thyroid hormone receptor (THR) isoforms and the development of techniques enabled the study of TH regulation of complex cellular processes (such as gene transcription). Recently we found that TH activates secondary transcription factors such as FOXO1, to amplify gene transcription; and also is a potent inducer of autophagy that was critical for fatty acid β-oxidation in the liver. This review summarizes the recent advancements in our understanding of TH regulation of gene expression of metabolic genes (via co-regulators/transcription factors and epigenetic control) and autophagy in the liver. Our deeper understanding of TH action recently has led to the development of tissue- and THR isoform-specific TH mimetics that may be useful for the treatment of metabolic disorders.
Source Title: MOLECULAR AND CELLULAR ENDOCRINOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/226736
ISSN: 03037207
18728057
DOI: 10.1016/j.mce.2017.02.018
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