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https://doi.org/10.3390/ijms21051645
| Title: | Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases | Authors: | Tripathi, Madhulika Yen, Paul Michael Singh, Brijesh Kumar |
Keywords: | Science & Technology Life Sciences & Biomedicine Physical Sciences Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry estrogen-related receptor alpha mitophagy mitochondrial turnover metabolic diseases non-alcoholic fatty liver disease (NAFLD) adipogenesis adaptive thermogenesis ORPHAN NUCLEAR RECEPTORS ERR-ALPHA GAMMA COACTIVATOR-1-ALPHA TRANSCRIPTIONAL COACTIVATOR SKELETAL-MUSCLE ENERGY-EXPENDITURE GENE-EXPRESSION ADIPOSE-TISSUE GENISTEIN HORMONE |
Issue Date: | 1-Mar-2020 | Publisher: | MDPI | Citation: | Tripathi, Madhulika, Yen, Paul Michael, Singh, Brijesh Kumar (2020-03-01). Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21 (5). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms21051645 | Abstract: | The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders. | Source Title: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | URI: | https://scholarbank.nus.edu.sg/handle/10635/226728 | ISSN: | 16616596 14220067 |
DOI: | 10.3390/ijms21051645 |
| Appears in Collections: | Elements Staff Publications |
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