Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms21051645
Title: Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases
Authors: Tripathi, Madhulika 
Yen, Paul Michael 
Singh, Brijesh Kumar 
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
estrogen-related receptor alpha
mitophagy
mitochondrial turnover
metabolic diseases
non-alcoholic fatty liver disease (NAFLD)
adipogenesis
adaptive thermogenesis
ORPHAN NUCLEAR RECEPTORS
ERR-ALPHA
GAMMA COACTIVATOR-1-ALPHA
TRANSCRIPTIONAL COACTIVATOR
SKELETAL-MUSCLE
ENERGY-EXPENDITURE
GENE-EXPRESSION
ADIPOSE-TISSUE
GENISTEIN
HORMONE
Issue Date: 1-Mar-2020
Publisher: MDPI
Citation: Tripathi, Madhulika, Yen, Paul Michael, Singh, Brijesh Kumar (2020-03-01). Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21 (5). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms21051645
Abstract: The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.
Source Title: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
URI: https://scholarbank.nus.edu.sg/handle/10635/226728
ISSN: 16616596
14220067
DOI: 10.3390/ijms21051645
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