Please use this identifier to cite or link to this item:
Title: Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia.
Authors: Ciardullo, Carmela
Szoltysek, Katarzyna
Zhou, Peixun
Pietrowska, Monika
Marczak, Lukasz
Willmore, Elaine
Enshaei, Amir
Walaszczyk, Anna
Ho, Jia Yee 
Rand, Vikki
Marshall, Scott
Hall, Andrew G
Harrison, Christine J
Soundararajan, Meera
Eswaran, Jeyanthy
Issue Date: 21-Dec-2021
Citation: Ciardullo, Carmela, Szoltysek, Katarzyna, Zhou, Peixun, Pietrowska, Monika, Marczak, Lukasz, Willmore, Elaine, Enshaei, Amir, Walaszczyk, Anna, Ho, Jia Yee, Rand, Vikki, Marshall, Scott, Hall, Andrew G, Harrison, Christine J, Soundararajan, Meera, Eswaran, Jeyanthy (2021-12-21). Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia.. Cancers 14 (1) : 23-. ScholarBank@NUS Repository.
Abstract: Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease with a highly variable clinical outcome. There are well-established CLL prognostic biomarkers that have transformed treatment and improved the understanding of CLL biology. Here, we have studied the clinical significance of two crucial B cell regulators, BACH2 (BTB and CNC homology 1, basic leucine zipper transcription factor 2) and BCL6 (B-cell CLL/lymphoma 6), in a cohort of 102 CLL patients and determined the protein interaction networks that they participate in using MEC-1 CLL cells. We observed that CLL patients expressing low levels of BCL6 and BACH2 RNA had significantly shorter overall survival (OS) than high BCL6- and BACH2-expressing cases. Notably, their low expression specifically decreased the OS of immunoglobulin heavy chain variable region-mutated (IGHV-M) CLL patients, as well as those with 11q and 13q deletions. Similar to the RNA data, a low BACH2 protein expression was associated with a significantly shorter OS than a high expression. There was no direct interaction observed between BACH2 and BCL6 in MEC-1 CLL cells, but they shared protein networks that included fifty different proteins. Interestingly, a prognostic index (PI) model that we generated, using integrative risk score values of BACH2 RNA expression, age, and 17p deletion status, predicted patient outcomes in our cohort. Taken together, these data have shown for the first time a possible prognostic role for BACH2 in CLL and have revealed protein interaction networks shared by BCL6 and BACH2, indicating a significant role for BACH2 and BCL6 in key cellular processes, including ubiquitination mediated B-cell receptor functions, nucleic acid metabolism, protein degradation, and homeostasis in CLL biology.
Source Title: Cancers
ISSN: 2072-6694
DOI: 10.3390/cancers14010023
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia. .pdf2.91 MBAdobe PDF




checked on Jun 6, 2023

Page view(s)

checked on Jun 8, 2023


checked on Jun 8, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.