Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers13071513
Title: Dysregulation of the Ubiquitin Proteasome System in Human Malignancies: A Window for Therapeutic Intervention
Authors: Fhu, Chee Wai 
Ali, Azhar 
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
ubiquitin proteasome system
dysregulation
chemoresistance
cancer
therapy
inhibitors
Issue Date: 1-Apr-2021
Publisher: MDPI
Citation: Fhu, Chee Wai, Ali, Azhar (2021-04-01). Dysregulation of the Ubiquitin Proteasome System in Human Malignancies: A Window for Therapeutic Intervention. CANCERS 13 (7). ScholarBank@NUS Repository. https://doi.org/10.3390/cancers13071513
Abstract: The ubiquitin proteasome system (UPS) governs the non-lysosomal degradation of oxi-dized, damaged, or misfolded proteins in eukaryotic cells. This process is tightly regulated through the activation and transfer of polyubiquitin chains to target proteins which are then recognized and degraded by the 26S proteasome complex. The role of UPS is crucial in regulating protein levels through degradation to maintain fundamental cellular processes such as growth, division, signal transduction, and stress response. Dysregulation of the UPS, resulting in loss of ability to maintain protein quality through proteolysis, is closely related to the development of various malignancies and tumorigenesis. Here, we provide a comprehensive general overview on the regulation and roles of UPS and discuss functional links of dysregulated UPS in human malignancies. Inhibitors developed against components of the UPS, which include U.S. Food and Drug Administration FDA-approved and those currently undergoing clinical trials, are also presented in this review.
Source Title: CANCERS
URI: https://scholarbank.nus.edu.sg/handle/10635/226659
ISSN: 2072-6694
DOI: 10.3390/cancers13071513
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