Please use this identifier to cite or link to this item: https://doi.org/10.3389/fcell.2021.673647
Title: Protein Lipidation by Palmitoylation and Myristoylation in Cancer
Authors: Fhu, Chee Wai 
Ali, Azhar 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Developmental Biology
protein lipidation
palmitoylation
myristoylation
depalmitoylation
metabolism
cancer
TRIS DIBENZYLIDENEACETONE DIPALLADIUM
N-MYRISTOYLTRANSFERASE
MEMBRANE-BINDING
DYNAMIC PALMITOYLATION
POTENT INHIBITORS
S-PALMITOYLATION
THIOESTERASES 1
DBA PALLADIUM
PALMOSTATIN B
FATTY-ACIDS
Issue Date: 20-May-2021
Publisher: FRONTIERS MEDIA SA
Citation: Fhu, Chee Wai, Ali, Azhar (2021-05-20). Protein Lipidation by Palmitoylation and Myristoylation in Cancer. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9. ScholarBank@NUS Repository. https://doi.org/10.3389/fcell.2021.673647
Abstract: Posttranslational modification of proteins with lipid moieties is known as protein lipidation. The attachment of a lipid molecule to proteins endows distinct properties, which affect their hydrophobicity, structural stability, localization, trafficking between membrane compartments, and influences its interaction with effectors. Lipids or lipid metabolites can serve as substrates for lipidation, and the availability of these lipid substrates are tightly regulated by cellular metabolism. Palmitoylation and myristoylation represent the two most common protein lipid modifications, and dysregulation of protein lipidation is strongly linked to various diseases such as metabolic syndromes and cancers. In this review, we present recent developments in our understanding on the roles of palmitoylation and myristoylation, and their significance in modulating cancer metabolism toward cancer initiation and progression.
Source Title: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/226655
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.673647
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