Please use this identifier to cite or link to this item: https://doi.org/10.1111/febs.16334
Title: EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms
Authors: Nachiyappan, A 
Gupta, N 
Taneja, R 
Keywords: EMT
G9a
GLP
cancer stem cells
drug resistance
metabolism
metastasis
methylation
therapeutics
Antineoplastic Agents
Disease Progression
Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition
Gene Expression Regulation, Neoplastic
Histocompatibility Antigens
Histone-Lysine N-Methyltransferase
Histones
Humans
Molecular Targeted Therapy
Neoplasm Metastasis
Neoplasm Proteins
Neoplasm Recurrence, Local
Neoplasms
Neoplastic Stem Cells
Treatment Failure
Issue Date: 1-Mar-2022
Publisher: Wiley
Citation: Nachiyappan, A, Gupta, N, Taneja, R (2022-03-01). EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms. FEBS Journal 289 (5) : 1329-1351. ScholarBank@NUS Repository. https://doi.org/10.1111/febs.16334
Abstract: Metastasis, therapy failure and tumour recurrence are major clinical challenges in cancer. The interplay between tumour-initiating cells (TICs) and epithelial–mesenchymal transition (EMT) drives tumour progression and spread. Recent advances have highlighted the involvement of epigenetic deregulation in these processes. The euchromatin histone lysine methyltransferase 1 (EHMT1) and euchromatin histone lysine methyltransferase 2 (EHMT2) that primarily mediate histone 3 lysine 9 di-methylation (H3K9me2), as well as methylation of non-histone proteins, are now recognised to be aberrantly expressed in many cancers. Their deregulated expression is associated with EMT, cellular plasticity and therapy resistance. In this review, we summarise evidence of their myriad roles in cancer metastasis, stemness and drug resistance. We discuss cancer-type specific molecular targets, context-dependent mechanisms and future directions of research in targeting EHMT1/EHMT2 for the treatment of cancer.
Source Title: FEBS Journal
URI: https://scholarbank.nus.edu.sg/handle/10635/226558
ISSN: 1742464X
17424658
DOI: 10.1111/febs.16334
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