Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ajps.2016.09.002
Title: Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling
Authors: Kou, Xiang
Chan, Lai Wah 
Sun, Changquan Calvin
Heng, Paul Wan Sia 
Keywords: Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Particle engineering
Shape modification
Lactose
Dry powder inhaler
AEROSOLIZED SALBUTAMOL SULFATE
TAILOR-MADE AUXILIARIES
DRUG-DELIVERY
CRYSTALS
INHALATION
MORPHOLOGY
SIZE
FORMULATIONS
PERFORMANCE
NUCLEATION
Issue Date: 1-Jan-2017
Publisher: HONG KONG ASIAMED PUBLISH HOUSE
Citation: Kou, Xiang, Chan, Lai Wah, Sun, Changquan Calvin, Heng, Paul Wan Sia (2017-01-01). Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 12 (1) : 59-65. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ajps.2016.09.002
Abstract: Dry powder inhalers are often formulated by attaching micronized drug particles onto carrier particles, which are generally lactose. In this study, commercially available lactose was air jet milled to produce unique slab-like coarse carrier particles, which have larger and rougher surfaces compared to other commercially available lactose. Two key processing factors, i.e., classifier speed and jet milling pressure, were systematically investigated. The largest fraction of slab-like particles in the resulting powder was obtained at a classifier speed of 3000 rpm. The slab-like coarse carrier particles are expected to exhibit superior performance than commercial lactose due to their unique surface properties.
Source Title: ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
URI: https://scholarbank.nus.edu.sg/handle/10635/225656
ISSN: 18180876
2221285X
DOI: 10.1016/j.ajps.2016.09.002
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