Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.phrs.2020.104901
Title: Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases
Authors: Cheong, Dorothy HJ 
Tan, Daniel WS 
Wong, Fred WS 
Thai, Tran 
Keywords: Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Respiratory diseases
Artemisinin
Lung
Cell proliferation
Inflammation
COVID-19
DIHYDROARTEMISININ-INDUCED APOPTOSIS
INDUCED AIRWAY INFLAMMATION
CELL LUNG-CARCINOMA
ARTESUNATE PROTECTS
CANCER-CELLS
A549 CELLS
CIGARETTE-SMOKE
OPEN-LABEL
INJURY
PATHWAY
Issue Date: 1-Aug-2020
Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation: Cheong, Dorothy HJ, Tan, Daniel WS, Wong, Fred WS, Thai, Tran (2020-08-01). Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases. PHARMACOLOGICAL RESEARCH 158. ScholarBank@NUS Repository. https://doi.org/10.1016/j.phrs.2020.104901
Abstract: Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatment of fever and chills, and has been recently approved for the treatment of malaria due to its endoperoxidase properties. Progressively, research has found that artemisinins displayed multiple pharmacological actions against inflammation, viral infections, and cell and tumour proliferation, making it effective against diseases. Moreover, it has displayed a relatively safe toxicity profile. The use of artemisinins against different respiratory diseases has been investigated in lung cancer models and inflammatory-driven respiratory disorders. These studies revealed the ability of artemisinins in attenuating proliferation, inflammation, invasion, and metastasis, and in inducing apoptosis. Artemisinins can regulate the expression of pro-inflammatory cytokines, nuclear factor-kappa B (NF-κB), matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), promote cell cycle arrest, drive reactive oxygen species (ROS) production and induce Bak or Bax-dependent or independent apoptosis. In this review, we aim to provide a comprehensive update of the current knowledge of the effects of artemisinins in relation to respiratory diseases to identify gaps that need to be filled in the course of repurposing artemisinins for the treatment of respiratory diseases. In addition, we postulate whether artemisinins can also be repurposed for the treatment of COVID-19 given its anti-viral and anti-inflammatory properties.
Source Title: PHARMACOLOGICAL RESEARCH
URI: https://scholarbank.nus.edu.sg/handle/10635/219421
ISSN: 1043-6618
1096-1186
DOI: 10.1016/j.phrs.2020.104901
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