Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.redox.2021.102012
Title: New roles for glutathione: Modulators of bacterial virulence and pathogenesis
Authors: Ku, JWK 
Gan, YH 
Keywords: Bacteria
Glutathione
Immune response
Pathogenesis
Thiol
Virulence
Antioxidants
Glutathione
Oxidation-Reduction
Sulfhydryl Compounds
Virulence
Issue Date: 1-Aug-2021
Publisher: Elsevier BV
Citation: Ku, JWK, Gan, YH (2021-08-01). New roles for glutathione: Modulators of bacterial virulence and pathogenesis. Redox Biology 44 : 102012-. ScholarBank@NUS Repository. https://doi.org/10.1016/j.redox.2021.102012
Abstract: Low molecular weight (LMW) thiols contain reducing sulfhydryl groups that are important for maintaining antioxidant defense in the cell. Aside from the traditional roles of LMW thiols as redox regulators in bacteria, glutathione (GSH) has been reported to affect virulence and bacterial pathogenesis. The role of GSH in virulence is diverse, including the activation of virulence gene expression and contributing to optimal biofilm formation. GSH can also be converted to hydrogen sulfide (H2S) which is important for the pathogenesis of certain bacteria. Besides GSH, some bacteria produce other LMW thiols such as mycothiol and bacillithiol that affect bacterial virulence. We discuss these newer reported functions of LMW thiols modulating bacterial pathogenesis either directly or indirectly and via modulation of the host immune system.
Source Title: Redox Biology
URI: https://scholarbank.nus.edu.sg/handle/10635/219269
ISSN: 22132317
DOI: 10.1016/j.redox.2021.102012
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