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https://doi.org/10.1016/j.jare.2020.05.010
Title: | Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential | Authors: | Sun, Hai-Jian Wu, Zhi-Yuan Nie, Xiao-Wei Wang, Xin-Yu Bian, Jin-Song |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics Hydrogen sulfide Liver disease Steatosis Fibrosis Cancer ISCHEMIA-REPERFUSION INJURY CYSTATHIONINE-GAMMA-LYASE HEPATOCELLULAR-CARCINOMA HEPATIC STEATOSIS OXIDATIVE STRESS ISCHEMIA/REPERFUSION INJURY TISSUE-INJURY RAT-LIVER 3RD GAS H2S |
Issue Date: | 1-Jan-2021 | Publisher: | ELSEVIER | Citation: | Sun, Hai-Jian, Wu, Zhi-Yuan, Nie, Xiao-Wei, Wang, Xin-Yu, Bian, Jin-Song (2021-01-01). Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. JOURNAL OF ADVANCED RESEARCH 27 : 127-135. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jare.2020.05.010 | Abstract: | Background: Over the last several decades, hydrogen sulfide (H2S) has been found to exert multiple physiological functions in mammal systems. The endogenous production of H2S is primarily mediated by cystathione β-synthase (CBS), cystathione γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST). These enzymes are widely expressed in the liver tissues and regulate hepatic functions by acting on various molecular targets. Aim of Review: In the present review, we will highlight the recent advancements in the cellular events triggered by H2S under liver diseases. The therapeutic effects of H2S donors on hepatic diseases will also be discussed. Key Scientific Concepts of Review: As a critical regulator of liver functions, H2S is critically involved in the etiology of various liver disorders, such as nonalcoholic steatohepatitis (NASH), hepatic fibrosis, hepatic ischemia/reperfusion (IR) injury, and liver cancer. Targeting H2S-producing enzymes may be a promising strategy for managing hepatic disorders. | Source Title: | JOURNAL OF ADVANCED RESEARCH | URI: | https://scholarbank.nus.edu.sg/handle/10635/219268 | ISSN: | 20901232 20901224 |
DOI: | 10.1016/j.jare.2020.05.010 |
Appears in Collections: | Staff Publications Elements |
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