Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jare.2020.05.010
Title: Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential
Authors: Sun, Hai-Jian
Wu, Zhi-Yuan 
Nie, Xiao-Wei
Wang, Xin-Yu
Bian, Jin-Song
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Hydrogen sulfide
Liver disease
Steatosis
Fibrosis
Cancer
ISCHEMIA-REPERFUSION INJURY
CYSTATHIONINE-GAMMA-LYASE
HEPATOCELLULAR-CARCINOMA
HEPATIC STEATOSIS
OXIDATIVE STRESS
ISCHEMIA/REPERFUSION INJURY
TISSUE-INJURY
RAT-LIVER
3RD GAS
H2S
Issue Date: 1-Jan-2021
Publisher: ELSEVIER
Citation: Sun, Hai-Jian, Wu, Zhi-Yuan, Nie, Xiao-Wei, Wang, Xin-Yu, Bian, Jin-Song (2021-01-01). Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. JOURNAL OF ADVANCED RESEARCH 27 : 127-135. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jare.2020.05.010
Abstract: Background: Over the last several decades, hydrogen sulfide (H2S) has been found to exert multiple physiological functions in mammal systems. The endogenous production of H2S is primarily mediated by cystathione β-synthase (CBS), cystathione γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST). These enzymes are widely expressed in the liver tissues and regulate hepatic functions by acting on various molecular targets. Aim of Review: In the present review, we will highlight the recent advancements in the cellular events triggered by H2S under liver diseases. The therapeutic effects of H2S donors on hepatic diseases will also be discussed. Key Scientific Concepts of Review: As a critical regulator of liver functions, H2S is critically involved in the etiology of various liver disorders, such as nonalcoholic steatohepatitis (NASH), hepatic fibrosis, hepatic ischemia/reperfusion (IR) injury, and liver cancer. Targeting H2S-producing enzymes may be a promising strategy for managing hepatic disorders.
Source Title: JOURNAL OF ADVANCED RESEARCH
URI: https://scholarbank.nus.edu.sg/handle/10635/219268
ISSN: 20901232
20901224
DOI: 10.1016/j.jare.2020.05.010
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