Please use this identifier to cite or link to this item: https://doi.org/10.2174/1570159X18666200905143550
Title: Role of Hydrogen Sulfide and Polysulfides in Neurological Diseases: Focus on Protein S-Persulfidation
Authors: Sun, Hai-Jian
Wu, Zhi-Yuan 
Nie, Xiao-Wei
Bian, Jin-Song
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Pharmacology & Pharmacy
Neurosciences & Neurology
Hydrogen sulfide
polysulfides
cysteine
S-Persulfidation
neurodegeneration
central nervous system
LONG-TERM POTENTIATION
CYSTATHIONINE BETA-SYNTHASE
NF-KAPPA-B
ALZHEIMERS-DISEASE
OXIDATIVE STRESS
NITRIC-OXIDE
D-SERINE
HUNTINGTONS-DISEASE
PARKINSONS-DISEASE
SULFANE SULFUR
Issue Date: 1-Jan-2021
Publisher: BENTHAM SCIENCE PUBL LTD
Citation: Sun, Hai-Jian, Wu, Zhi-Yuan, Nie, Xiao-Wei, Bian, Jin-Song (2021-01-01). Role of Hydrogen Sulfide and Polysulfides in Neurological Diseases: Focus on Protein S-Persulfidation. CURRENT NEUROPHARMACOLOGY 19 (6) : 868-884. ScholarBank@NUS Repository. https://doi.org/10.2174/1570159X18666200905143550
Abstract: Hydrogen sulfide (H2S) and hydrogen polysulfides are recognized as important signaling molecules that are generated physiologically in the body, including the central nervous system (CNS). Studies have shown that these two molecules are involved in cytoprotection against oxida-tive stress and inflammatory response. In the brain system, H2S and polysulfides exert multiple functions in both health and diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington's disease (HD), memory decline, and glioma. Mechanistically, S-Persulfidation (also known as S-sulfuration or S-sulfhydration) of target proteins is believed to be a fundamental mechanism that underlies H2S-regulated signaling pathways. Cysteine S-Persulfidation is an important paradigm of post translational protein modification in the process of H2S signaling. This model is established as a critical redox mechanism to regulate numerous biological functions, especially in H2S-mediated neuroprotection and neurogenesis. Although the current research of S-Persulfida-tion is still in its infancy, accumulative evidence suggests that protein S-Persulfidation may share similar characteristics with protein S-nitrosylation. In this review, we will provide a comprehensive insight into the S-Persulfidation biology of H2S and polysulfides in neurological ailments and pre-sume potential avenues for therapeutic development in these disorders based on S-Persulfidation of target proteins.
Source Title: CURRENT NEUROPHARMACOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/219266
ISSN: 1570159X
18756190
DOI: 10.2174/1570159X18666200905143550
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