Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.celrep.2016.07.029
Title: Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice
Authors: Tsai, Shih-Yin 
Rodriguez, Ariana A
Dastidar, Somasish G
Del Greco, Elizabeth
Carr, Kaili Lia
Sitzmann, Joanna M
Academia, Emmeline C
Viray, Christian Michael
Martinez, Lizbeth Leon
Kaplowitz, Brian Stephen
Ashe, Travis D
La Spada, Albert R
Kennedy, Brian K
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
ADIPOSE-TISSUE
DIABETIC-NEPHROPATHY
GENETIC ARCHITECTURE
SEXUAL-DIMORPHISM
MTOR
SENSITIVITY
LACKING
RISK
PHOSPHORYLATION
INFLAMMATION
Issue Date: 16-Aug-2016
Publisher: CELL PRESS
Citation: Tsai, Shih-Yin, Rodriguez, Ariana A, Dastidar, Somasish G, Del Greco, Elizabeth, Carr, Kaili Lia, Sitzmann, Joanna M, Academia, Emmeline C, Viray, Christian Michael, Martinez, Lizbeth Leon, Kaplowitz, Brian Stephen, Ashe, Travis D, La Spada, Albert R, Kennedy, Brian K (2016-08-16). Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. CELL REPORTS 16 (7) : 1903-1914. ScholarBank@NUS Repository. https://doi.org/10.1016/j.celrep.2016.07.029
Abstract: Obesity is a major risk factor driving the global type II diabetes pandemic. However, the molecular factors linking obesity to disease remain to be elucidated. Gender differences are apparent in humans and are also observed in murine models. Here, we link these differences to expression of eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1), which, upon HFD feeding, becomes significantly reduced in the skeletal muscle and adipose tissue of male but not female mice. Strikingly, restoring 4E-BP1 expression in male mice protects them against HFD-induced obesity and insulin resistance. Male 4E-BP1 transgenic mice also exhibit reduced white adipose tissue accumulation accompanied by decreased circulating levels of leptin and triglycerides. Importantly, transgenic 4E-BP1 male mice are also protected from aging-induced obesity and metabolic decline on a normal diet. These results demonstrate that 4E-BP1 is a gender-specific suppressor of obesity that regulates insulin sensitivity and energy metabolism.
Source Title: CELL REPORTS
URI: https://scholarbank.nus.edu.sg/handle/10635/218742
ISSN: 22111247
DOI: 10.1016/j.celrep.2016.07.029
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