Please use this identifier to cite or link to this item: https://doi.org/10.1080/10520295.2021.1912827
Title: Cytoplasmic phosphorylated ERK1/2 expression in patients with melanoma is associated with tumor stage and metastasis
Authors: Yen-Shuo Tseng
Pei-Ru Wu
Jeng-Wei Lu 
Yu-Fen Wang
Kun-Tu Yeh
Shu-Hui Lin
Keywords: Cytoplasm
ERK1/2
extracellular signal-regulated kinase 1/2
human
immunohistochemistry
melanoma
phosphorylation
Issue Date: 27-Apr-2021
Publisher: Taylor & Francis
Citation: Yen-Shuo Tseng, Pei-Ru Wu, Jeng-Wei Lu, Yu-Fen Wang, Kun-Tu Yeh, Shu-Hui Lin (2021-04-27). Cytoplasmic phosphorylated ERK1/2 expression in patients with melanoma is associated with tumor stage and metastasis. Biotechnic & Histochemistry 97 (02) : 118-125. ScholarBank@NUS Repository. https://doi.org/10.1080/10520295.2021.1912827
Abstract: Melanoma is the cause of most deaths from skin cancer. The extracellular signal-regulated kinase 1/2 (ERK1/2) pathway has been reported to participate in progression of melanoma in fair skinned populations. ERK1/2 is found in both the cytoplasm and nucleus of cells, and phosphorylated ERK1/2 has been implicated in tumor progression. We investigated the relation between melanoma progression and expression of cytoplasmic and nuclear phosphorylated ERK1/2. We examined 34 surgically resected melanomas and investigated their clinicopathologic characteristics. We found immunostaining of phosphorylated ERK1/2 in all melanomas and faint staining in benign nevi. We found expression of cytoplasmic phosphorylated ERK1/2 in most melanomas; however, nuclear phosphorylated ERK1/2 expression was found in only five melanomas. Expression of cytoplasmic phosphorylated ERK1/2 was related to the tumor stage in melanoma. Nine of 10 cases of distant metastasis were positive for cytoplasmic phosphorylated ERK1/2. Our findings suggest that phosphorylated ERK1/2 expression is relevant to clinical pathology and that in melanoma patients, phosphorylated ERK1/2 expression is found in both the cytoplasm and nucleus. Our findings suggest that cytoplasmic phosphorylated ERK1/2 participates in progression of melanoma and that it could be a useful target for clinical treatment of melanoma.
Source Title: Biotechnic & Histochemistry
URI: https://scholarbank.nus.edu.sg/handle/10635/217049
ISSN: 1052-0295
DOI: 10.1080/10520295.2021.1912827
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