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https://doi.org/10.1038/s41390-022-01941-z
Title: | Prevalence and predictors of metabolically healthy obesity in severely obese Asian children. | Authors: | Ooi, Delicia Shu Qin Ong, Siong Gim Lee, Owen Ming Hao Chan, Yiong Huak Lim, Yvonne Yijuan Ho, Cindy Wei Li Tay, Veronica Vijaya, K Loke, Kah Yin Sng, Andrew Anjian Lee, Yung Seng |
Issue Date: | 7-Feb-2022 | Publisher: | Springer Science and Business Media LLC | Citation: | Ooi, Delicia Shu Qin, Ong, Siong Gim, Lee, Owen Ming Hao, Chan, Yiong Huak, Lim, Yvonne Yijuan, Ho, Cindy Wei Li, Tay, Veronica, Vijaya, K, Loke, Kah Yin, Sng, Andrew Anjian, Lee, Yung Seng (2022-02-07). Prevalence and predictors of metabolically healthy obesity in severely obese Asian children.. Pediatr Res. ScholarBank@NUS Repository. https://doi.org/10.1038/s41390-022-01941-z | Abstract: | BACKGROUND: Obese individuals who have little or no metabolic syndrome components are proposed to be "metabolically healthy obese (MHO)". This study aim to evaluate the prevalence of MHO and examine the predictors associated with MHO in a multi-ethnic Asian cohort of severely obese children. METHODS: This study included a cross-sectional cohort of 406 Chinese, Malay and Indian children aged 5-20 years old with BMI for age ≥ 97th percentile. Metabolic syndrome (MS) and metabolic health (MH) definitions based on the presence or absence of metabolic abnormalities (High triglycerides, low HDL cholesterol, elevated blood pressure and high glucose) were used to define MHO in the cohort. RESULTS: The prevalence of MHO is 63.5% by MS definition and 22.4% by MH definition. Maternal healthy metabolic status (OR: 2.47), age (OR: 0.83, 0.80), paternal obesity (OR: 0.48, 0.53), Malay (OR: 1.97) and Indian ethnicity (OR: 6.38, 3.21) (compared to Chinese ethnicity) are independent predictors for MHO phenotype based on different MHO definitions. CONCLUSIONS: Adiposity measures are not associated with MHO phenotype, but instead younger age, maternal healthy metabolic status, absence of paternal obesity, Malay and Indian ethnicity are independent predictors for MHO phenotype in a multi-ethnic Asian cohort of severely obese children. IMPACT: The prevalence of metabolically healthy obese (MHO) in our multi-ethnic Asian cohort of severely obese children is 63.5% and 22.4%, respectively, based on different MHO definitions. Adiposity measures are not associated with the MHO phenotype. There are other factors that contribute to the metabolic phenotype in obese individuals. Younger age, maternal healthy metabolic status, absence of paternal obesity, Malay and Indian ethnicity are independent predictors for MHO phenotype. Parental influence is important in predicting metabolic health in obese individuals. | Source Title: | Pediatr Res | URI: | https://scholarbank.nus.edu.sg/handle/10635/216177 | ISSN: | 00313998 15300447 |
DOI: | 10.1038/s41390-022-01941-z |
Appears in Collections: | Staff Publications Elements |
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Manuscript_R2_clean.docx | Accepted version | 130.72 kB | Microsoft Word XML | OPEN | None | View/Download |
Tables_revised.docx | Accepted version | 22.02 kB | Microsoft Word XML | OPEN | None | View/Download |
Supplementary Material_R2.docx | Accepted version | 17.59 kB | Microsoft Word XML | OPEN | None | View/Download |
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