Please use this identifier to cite or link to this item: https://doi.org/10.1097/MOP.0b013e3283658fba
Title: Genetics of nonsyndromic obesity
Authors: Lee, Yung Seng 
Keywords: Science & Technology
Life Sciences & Biomedicine
Pediatrics
adiposity
epigenetics
genetics
obesity
MELANOCORTIN-4 RECEPTOR GENE
BODY-MASS INDEX
WEIGHT-LOSS
FUNCTIONAL-CHARACTERIZATION
FATTY LIVER
MUTATIONS
ASSOCIATION
POLYMORPHISMS
IDENTIFICATION
ADOLESCENTS
Issue Date: 1-Dec-2013
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: Lee, Yung Seng (2013-12-01). Genetics of nonsyndromic obesity. CURRENT OPINION IN PEDIATRICS 25 (6) : 666-673. ScholarBank@NUS Repository. https://doi.org/10.1097/MOP.0b013e3283658fba
Abstract: PURPOSE OF REVIEW: Common obesity is widely regarded as a complex, multifactorial trait influenced by the 'obesogenic' environment, sedentary behavior, and genetic susceptibility contributed by common and rare genetic variants. This review describes the recent advances in understanding the role of genetics in obesity. RECENT FINDINGS: New susceptibility loci and genetic variants are being uncovered, but the collective effect is relatively small and could not explain most of the BMI heritability. Yet-to-be identified common and rare variants, epistasis, and heritable epigenetic changes may account for part of the 'missing heritability'. Evidence is emerging about the role of epigenetics in determining obesity susceptibility, mediating developmental plasticity, which confers obesity risk from early life experiences. Genetic prediction scores derived from selected genetic variants, and also differential DNA methylation levels and methylation scores, have been shown to correlate with measures of obesity and response to weight loss intervention. Genetic variants, which confer susceptibility to obesity-related morbidities like nonalcoholic fatty liver disease, were also discovered recently. SUMMARY: We can expect discovery of more rare genetic variants with the advent of whole exome and genome sequencing, and also greater understanding of epigenetic mechanisms by which environment influences genetic expression and which mediate the gene-environment interaction. Copyright © 2013 Lippincott Williams & Wilkins.
Source Title: CURRENT OPINION IN PEDIATRICS
URI: https://scholarbank.nus.edu.sg/handle/10635/215936
ISSN: 10408703
1531698X
DOI: 10.1097/MOP.0b013e3283658fba
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