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Title: A metal-organic-framework incorporated vascular graft for sustained nitric oxide generation and long-term vascular patency
Authors: Zhang, X
Wang, Y 
Liu, J
Shi, J
Mao, D 
Midgley, AC
Leng, X
Kong, D
Wang, Z
Liu, B 
Wang, S
Issue Date: 1-Oct-2021
Publisher: Elsevier BV
Citation: Zhang, X, Wang, Y, Liu, J, Shi, J, Mao, D, Midgley, AC, Leng, X, Kong, D, Wang, Z, Liu, B, Wang, S (2021-10-01). A metal-organic-framework incorporated vascular graft for sustained nitric oxide generation and long-term vascular patency. Chemical Engineering Journal 421 : 129577-129577. ScholarBank@NUS Repository.
Abstract: Copper-MOFs (Cu-MOFs) have been reported to demonstrate great potential as cardiovascular biomaterials, due to enhanced catalytic ability of Cu2+ to generate nitric oxide (NO) from endogenous S-nitrosothiols (RSNOs). However, free Cu-MOFs usually show rapid degradation under physiological conditions, resulting in short catalytic half-life and risk of copper ion toxicity. Therefore, how to increase the stability of Cu-MOFs is of great importance in cardiovascular biomaterials research. Herein, we chose M199 MOF as an example and developed Cu-MOF-based scaffold, using the electrospinning method to embed Cu-MOF nanoparticles into polycaprolactone (PCL) fibers. Entrapment of Cu-MOF nanoparticles within PCL could simultaneously enhance Cu-MOF stability in serum and allow for long-term NO catalytic activity, as assessed by in vitro assays and using in situ implantation models. Additionally, the optimized concentration of Cu-MOFs loaded within the scaffolds significantly promoted endothelial cell (EC) migration and increased acetylated low-density lipoprotein (Ac-LDL) uptake. Moreover, Cu-MOF-based scaffolds dramatically inhibited platelet adhesion and activation, which markedly reduced acute thrombosis in arterio-venous shunt models. In situ implantation experiments revealed that the PCL/Cu-MOF scaffolds accelerated the formation of an intact endothelial monolayer. Together, these results suggest that the incorporation of Cu-MOFs into electrospun fibers could serve as a promising approach to achieve stable catalytic performance and long-term activity required for implant materials.
Source Title: Chemical Engineering Journal
ISSN: 13858947
DOI: 10.1016/j.cej.2021.129577
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