Please use this identifier to cite or link to this item: https://doi.org/10.1021/acs.chemmater.1c01173
Title: Metabolizable Photosensitizer with Aggregation-Induced Emission for Photodynamic Therapy
Authors: Wu, Wenbo
Shi, Leilei
Duan, Yukun 
Xu, Shidang 
Gao, Xihui
Zhu, Xinyuan
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Physical
Materials Science, Multidisciplinary
Chemistry
Materials Science
Issue Date: 28-Jul-2021
Publisher: AMER CHEMICAL SOC
Citation: Wu, Wenbo, Shi, Leilei, Duan, Yukun, Xu, Shidang, Gao, Xihui, Zhu, Xinyuan, Liu, Bin (2021-07-28). Metabolizable Photosensitizer with Aggregation-Induced Emission for Photodynamic Therapy. CHEMISTRY OF MATERIALS 33 (15) : 5974-5980. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.chemmater.1c01173
Abstract: As a noninvasive treatment option, photodynamic therapy (PDT) offers light-controlled spatiotemporal precision. However, the current clinical practice requires the patients to avoid light exposure for days to weeks post PDT treatment due to the retention of photosensitizers (PSs) in the living body. In addition, traditional PSs suffer from quenched fluorescence and reduced 1O2 production in nanoparticles (NPs) or the aggregate state. Herein, an efficient metabolizable type-II photosensitizer FBD with aggregation-induced emission characteristics is developed and processed into NPs, which demonstrates good anti-tumor PDT efficiency in mice models. Importantly, FBD can be gradually oxidized after PDT by endogenous hypochlorite (ClO-) in the living body and subsequently excreted through urine within 24 h after PS administration. The designed metabolizable therapeutic agent addresses the key limitation of traditional PDT, showing great potential for clinical translation.
Source Title: CHEMISTRY OF MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/215258
ISSN: 08974756
15205002
DOI: 10.1021/acs.chemmater.1c01173
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