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https://doi.org/10.1002/chem.202100406
Title: | Organic Nanoparticles with Persistent Luminescence for In Vivo Afterglow Imaging-Guided Photodynamic Therapy | Authors: | Zheng, Xiaokun Wu, Wenbo Zheng, Yue Ding, Yiwen Xiang, Yu Liu, Bin Tong, Aijun |
Keywords: | Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry biochemistry aggregation-induced emission organic nanoparticles photodynamic therapy tumors |
Issue Date: | 17-Mar-2021 | Publisher: | WILEY-V C H VERLAG GMBH | Citation: | Zheng, Xiaokun, Wu, Wenbo, Zheng, Yue, Ding, Yiwen, Xiang, Yu, Liu, Bin, Tong, Aijun (2021-03-17). Organic Nanoparticles with Persistent Luminescence for In Vivo Afterglow Imaging-Guided Photodynamic Therapy. CHEMISTRY-A EUROPEAN JOURNAL 27 (23) : 6911-6916. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.202100406 | Abstract: | Optical imaging-guided photodynamic therapy (PDT), with precise localization and non-invasive treatment of tumors, is an emerging technique with great potential for cancer therapy. However, impaired by tissue auto-fluorescence that causes low signal-to-background ratio (SBR), most fluorescence imaging systems show poor sensitivity to tumors in vivo. In this study, we synthesized organic nanoparticles (ONPs) with persistent luminescence and good biocompatibility for afterglow imaging-guided PDT. The ONPs displayed near-infrared light emission with half-life time at minute level, which offered high SBR and good tissue penetration for in vivo afterglow tumor imaging. Taking advantage of their abundant singlet oxygen generation by NIR laser irradiation guided to the tumor sites, the ONPs also enabled imaging-guided PDT for efficient suppression of tumor growth in mice with minimal damage to major organs. | Source Title: | CHEMISTRY-A EUROPEAN JOURNAL | URI: | https://scholarbank.nus.edu.sg/handle/10635/215136 | ISSN: | 0947-6539,1521-3765 | DOI: | 10.1002/chem.202100406 |
Appears in Collections: | Elements Staff Publications |
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Manuscript.doc | Submitted version | 4.9 MB | Microsoft Word | OPEN | Post-print | View/Download |
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