Please use this identifier to cite or link to this item: https://doi.org/10.1002/chem.202100406
Title: Organic Nanoparticles with Persistent Luminescence for In Vivo Afterglow Imaging-Guided Photodynamic Therapy
Authors: Zheng, Xiaokun
Wu, Wenbo 
Zheng, Yue
Ding, Yiwen
Xiang, Yu
Liu, Bin 
Tong, Aijun
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
biochemistry
aggregation-induced emission
organic nanoparticles
photodynamic therapy
tumors
Issue Date: 17-Mar-2021
Publisher: WILEY-V C H VERLAG GMBH
Citation: Zheng, Xiaokun, Wu, Wenbo, Zheng, Yue, Ding, Yiwen, Xiang, Yu, Liu, Bin, Tong, Aijun (2021-03-17). Organic Nanoparticles with Persistent Luminescence for In Vivo Afterglow Imaging-Guided Photodynamic Therapy. CHEMISTRY-A EUROPEAN JOURNAL 27 (23) : 6911-6916. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.202100406
Abstract: Optical imaging-guided photodynamic therapy (PDT), with precise localization and non-invasive treatment of tumors, is an emerging technique with great potential for cancer therapy. However, impaired by tissue auto-fluorescence that causes low signal-to-background ratio (SBR), most fluorescence imaging systems show poor sensitivity to tumors in vivo. In this study, we synthesized organic nanoparticles (ONPs) with persistent luminescence and good biocompatibility for afterglow imaging-guided PDT. The ONPs displayed near-infrared light emission with half-life time at minute level, which offered high SBR and good tissue penetration for in vivo afterglow tumor imaging. Taking advantage of their abundant singlet oxygen generation by NIR laser irradiation guided to the tumor sites, the ONPs also enabled imaging-guided PDT for efficient suppression of tumor growth in mice with minimal damage to major organs.
Source Title: CHEMISTRY-A EUROPEAN JOURNAL
URI: https://scholarbank.nus.edu.sg/handle/10635/215136
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.202100406
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