Please use this identifier to cite or link to this item: https://doi.org/10.1039/d0na00985g
Title: Near-infrared light excited photodynamic anticancer therapy based on UCNP@AIEgen nanocomposite
Authors: Ding, S
Wu, W 
Peng, T
Pang, W
Jiang, P
Zhan, Q
Qi, S
Wei, X
Gu, B
Liu, B 
Issue Date: 21-Apr-2021
Publisher: Royal Society of Chemistry (RSC)
Citation: Ding, S, Wu, W, Peng, T, Pang, W, Jiang, P, Zhan, Q, Qi, S, Wei, X, Gu, B, Liu, B (2021-04-21). Near-infrared light excited photodynamic anticancer therapy based on UCNP@AIEgen nanocomposite. Nanoscale Advances 3 (8) : 2325-2333. ScholarBank@NUS Repository. https://doi.org/10.1039/d0na00985g
Abstract: Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, features non-invasiveness, few side-effects, high spatial resolution,etc.The advancement of PDT has been significantly restricted by the penetration depth of the excitation light. Herein, an effective fluorogen, TBD, with aggregation-induced emission characteristics (AIEgen) and high reactive-oxygen-species (ROS) generation efficiency was reported and integrated with a near infrared (NIR) light excitable upconversion nanoparticle (UCNP) to construct NIR light excitable UCNP@TBD nanocomposites. The formed nanocomposite has excellent photostability, good biocompatibility, and efficient ROS generation under NIR light excitationviaFörster resonance energy transfer (FRET), enabling NIR light excited PDT. Moreover, the proposed NIR light excited PDT can break the impasse between the penetration depth and excitation volume in conventional PDT, effectively improving the anticancer therapeutic outcome.In vitrocancer cell ablation andin vivotumor growth inhibition validated that the proposed UCNP@TBD nanocomposite is a promising NIR light excitable PDT agent with great potential for future translational research.
Source Title: Nanoscale Advances
URI: https://scholarbank.nus.edu.sg/handle/10635/215108
ISSN: 2516-0230
DOI: 10.1039/d0na00985g
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
UCNP@AIEgen Final.docxSubmitted version10.79 MBMicrosoft Word XML

OPEN

Post-printView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.