Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tranon.2018.06.010
Title: Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter Study
Authors: Surov, Alexey
Ginat, Daniel T
Lim, Tchoyoson 
Cabada, Teresa
Baskan, Ozdil
Schob, Stefan
Meyer, Hans Jonas
Gihr, Georg Alexander
Horvath-Rizea, Diana
Hamerla, Gordian
Hoffmann, Karl Titus
Wienke, Andreas
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
MRI ASSESSMENT
ASSOCIATIONS
PREDICTION
CARCINOMA
ADC
Issue Date: 1-Oct-2018
Publisher: ELSEVIER SCIENCE INC
Citation: Surov, Alexey, Ginat, Daniel T, Lim, Tchoyoson, Cabada, Teresa, Baskan, Ozdil, Schob, Stefan, Meyer, Hans Jonas, Gihr, Georg Alexander, Horvath-Rizea, Diana, Hamerla, Gordian, Hoffmann, Karl Titus, Wienke, Andreas (2018-10-01). Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter Study. TRANSLATIONAL ONCOLOGY 11 (5) : 1074-1079. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tranon.2018.06.010
Abstract: Low grade meningiomas have better prognosis than high grade meningiomas. The aim of this study was to measure apparent diffusion coefficient (ADC) histogram analysis parameters in different meningiomas in a large multicenter sample and to analyze the possibility of several parameters for predicting tumor grade and proliferation potential. Overall, 148 meningiomas from 7 institutions were evaluated in this retrospective study. Grade 1 lesions were diagnosed in 101 (68.2%) cases, grade 2 in 41 (27.7%) patients, and grade 3 in 6 (4.1%) patients. All tumors were investigated by MRI (1.5 T scanner) by using diffusion weighted imaging (b values of 0 and 1000 s/mm2). For every lesion, the following parameters were calculated: mean ADC, maximum ADC, minimum ADC, median ADC, mode ADC, ADC percentiles P10, P25, P75, P90, kurtosis, skewness, and entropy. The comparison of ADC values was performed by Mann–Whitney-U test. Correlation between different ADC parameters and KI 67 was calculated by Spearman's rank correlation coefficient. Grade 2/3 meningiomas showed statistically significant lower ADC histogram analysis parameters in comparison to grade 1 tumors, especially ADC median. A threshold value of 0.82 for ADC median to predict tumor grade was estimated (sensitivity = 82.2%, specificity = 63.8%, accuracy = 76.4%, positive and negative predictive values were 83% and 62.5%, respectively). All ADC parameters except maximum ADC showed weak significant correlations with KI 67, especially ADC P25 (P = −.340, P =.0001).
Source Title: TRANSLATIONAL ONCOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/213557
ISSN: 19365233
DOI: 10.1016/j.tranon.2018.06.010
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