Please use this identifier to cite or link to this item: https://doi.org/10.1159/000520903
Title: Effects of Sodium-Glucose Cotransporter 2 on Amputation Events: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials.
Authors: See, Ray Meng
Teo, Yao Neng
Teo, Yao Hao
Syn, Nicholas L
Yip, Alicia Swee Yan
Leong, Shariel
Wee, Caitlin Fern
Cheong, Alex Jia Yang
Lee, Chi-Hang 
Chan, Mark Yan-Yee 
Yeo, Tiong Cheng 
Wong, Raymond CC 
Chang, Peter
Hong, Choon Chiet
Chai, Ping 
Sia, Ching-Hui 
Keywords: Amputations
Sodium-glucose cotransporter 2 inhibitors
Issue Date: 23-Dec-2021
Publisher: S. Karger AG
Citation: See, Ray Meng, Teo, Yao Neng, Teo, Yao Hao, Syn, Nicholas L, Yip, Alicia Swee Yan, Leong, Shariel, Wee, Caitlin Fern, Cheong, Alex Jia Yang, Lee, Chi-Hang, Chan, Mark Yan-Yee, Yeo, Tiong Cheng, Wong, Raymond CC, Chang, Peter, Hong, Choon Chiet, Chai, Ping, Sia, Ching-Hui (2021-12-23). Effects of Sodium-Glucose Cotransporter 2 on Amputation Events: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials.. Pharmacology 107 : 123-130. ScholarBank@NUS Repository. https://doi.org/10.1159/000520903
Abstract: INTRODUCTION: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are increasingly utilized in the treatment of diabetes mellitus as well as therapeutic extra-glycemic effects. However, there are still concerns over complications such as amputation events, given the results from the Canagliflozin Cardiovascular Assessment Study (CANVAS) trial. Hence, we conducted a systematic review and meta-analysis of randomized-controlled trials to investigate the effect of SGLT2 inhibitors on amputation events. METHODS: Four electronic databases (PubMed, Embase, Cochrane, and SCOPUS) were searched on November 21, 2020, for articles published from January 1, 2000, up to November 21, 2020, for studies that examined the effect of SGLT2 inhibitors on amputation events. Random-effect pair-wise meta-analysis for hazard ratios and fixed-effect Peto odds ratio meta-analysis were utilized to summarize the studies. RESULTS: A total of 15 randomized-controlled trials were included with a combined cohort of 63,716 patients. We demonstrated that there was no significant difference in amputation events across different types of SGLT2 inhibitors, different baseline populations, and different duration of SGLT2 inhibitor use. DISCUSSION/CONCLUSIONS: In this meta-analysis, SGLT2 inhibitors were not associated with a significant difference in amputation events.
Source Title: Pharmacology
URI: https://scholarbank.nus.edu.sg/handle/10635/213139
ISSN: 00317012
14230313
DOI: 10.1159/000520903
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