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Title: Autophagy modulators: Mechanistic aspects and drug delivery systems
Authors: Tavakol, S.
Ashrafizadeh, M.
Deng, S. 
Azarian, M.
Abdoli, A.
Motavaf, M.
Poormoghadam, D.
Khanbabaei, H.
Ghasemipour Afshar, E.
Mandegary, A.
Pardakhty, A.
Yap, C.T. 
Mohammadinejad, R.
Prem Kumar, A. 
Keywords: AMPK
Combination therapy
Issue Date: 2019
Publisher: MDPI AG
Citation: Tavakol, S., Ashrafizadeh, M., Deng, S., Azarian, M., Abdoli, A., Motavaf, M., Poormoghadam, D., Khanbabaei, H., Ghasemipour Afshar, E., Mandegary, A., Pardakhty, A., Yap, C.T., Mohammadinejad, R., Prem Kumar, A. (2019). Autophagy modulators: Mechanistic aspects and drug delivery systems. Biomolecules 9 (10) : 530. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. This knowledge will help scientists find approaches to manipulate tumor and pathologic cells in order to enhance cellular sensitivity to therapeutics and treat them. Although some conventional therapeutics suffer from poor solubility, bioavailability and controlled release mechanisms, it appears that novel nanoplatforms overcome these obstacles and have led to the design of a theranostic-controlled drug release system with high solubility and active targeting and stimuli-responsive potentials. In this review, we discuss autophagy modulators-related signaling pathways and some of the drug delivery strategies that have been applied to the field of therapeutic application of autophagy modulators. Moreover, we describe how therapeutics will target various steps of the autophagic machinery. Furthermore, nano drug delivery platforms for autophagy targeting and co-delivery of autophagy modulators with chemotherapeutics/siRNA, are also discussed. � 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Biomolecules
ISSN: 2218273X
DOI: 10.3390/biom9100530
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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