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Title: Axial growth and lens power loss at myopia onset in singaporean children
Authors: Jos, R.
Sebastian, D.
Iribarren, R.
Lanca, C.
Saw, S.-M. 
Keywords: biometry
crystalline lens
myopia onset
Issue Date: 2019
Publisher: Association for Research in Vision and Ophthalmology Inc.
Citation: Jos, R., Sebastian, D., Iribarren, R., Lanca, C., Saw, S.-M. (2019). Axial growth and lens power loss at myopia onset in singaporean children. Investigative Ophthalmology and Visual Science 60 (8) : 3091-3099. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: PURPOSE. We studied biometry changes before and after myopia onset in a cohort of Singaporean children. METHODS. All data were taken from the Singapore Cohort Study of the Risk Factors for Myopia (SCORM). Participants underwent refraction and biometry measurements with a follow-up of 3 to 6 years. The longitudinal ocular biometry (spherical equivalent refraction, axial length, and lens power) changes were compared between children who suffered myopia during the study (N = 303), em etropic children (N = 490), and children myopic at baseline (N = 509). RESULTS. At myopia onset, the myopic shift increased to 0.50 diopters (D)/y or more in new myopes compared to the minor changes in emmetropes of the same age. New myopes had higher axial growth rates than emmetropes, even years before myopia onset (0.37 and 0.14 mm/y, respectively; ANOVA with Bonferroni post hoc test, P < 0.001). After onset, the change in both parameters slowed down gradually, but significantly (P < 0.05). In new myopes, lens power loss (-.71 D/y) was significantly higher up to 1 year before myopia onset compared to emmetropes (-.46 D/y), after which lens power loss slows down rapidly. At age 7 years, (future) new myopes had lens power values close to those of emmetropes (25.12 and 25.23 D, respectively), while later these values approached those of children who were myopic at baseline (23.06 and 22.79 D, respectively, compared to 23.71 D for emmetropes; P < 0.001). CONCLUSIONS. New myopes have higher axial growth rates and lens power loss before myopia onset than persistent emmetropes. © 2019 The Authors. All rights reserved.
Source Title: Investigative Ophthalmology and Visual Science
ISSN: 0146-0404
DOI: 10.1167/iovs.18-26247
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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