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Title: Fangchinoline, a bisbenzylisoquinoline alkaloid can modulate cytokine-impelled apoptosis via the dual regulation of NF-?B and AP-1 pathways
Authors: Jung, Y.Y.
Shanmugam, M.K.
Chinnathambi, A.
Alharbi, S.A.
Shair, O.H.M.
Um, J.-Y.
Sethi, G. 
Ahn, K.S.
Keywords: AP-1
Issue Date: 2019
Publisher: MDPI AG
Citation: Jung, Y.Y., Shanmugam, M.K., Chinnathambi, A., Alharbi, S.A., Shair, O.H.M., Um, J.-Y., Sethi, G., Ahn, K.S. (2019). Fangchinoline, a bisbenzylisoquinoline alkaloid can modulate cytokine-impelled apoptosis via the dual regulation of NF-?B and AP-1 pathways. Molecules 24 (17) : 3127. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Fangchinoline (FCN) derived from Stephaniae tetrandrine S. Moore can be employed to treat fever, inflammation, rheumatism arthralgia, edema, dysuria, athlete’s foot, and swollen wet sores. FCN can exhibit a plethora of anti-neoplastic effects although its precise mode of action still remains to be deciphered. Nuclear factor-?B (NF-?B) and activator protein-1 (AP-1) can closely regulate carcinogenesis and thus we analyzed the possible action of FCN may have on these two signaling cascades in tumor cells. The effect of FCN on NF-?B and AP-1 signaling cascades and its downstream functions was deciphered using diverse assays in both human chronic myeloid leukemia (KBM5) and multiple myeloma (U266). FCN attenuated growth of both leukemic and multiple myeloma cells and repressed NF-?B, and AP-1 activation through diverse mechanisms, including attenuation of phosphorylation of I?B kinase (IKK) and p65. Furthermore, FCN could also cause significant enhancement in TNF?-driven apoptosis as studied by various molecular techniques. Thus, FCN may exhibit potent anti-neoplastic effects by affecting diverse oncogenic pathways and may be employed as pro-apoptotic agent against various malignancies. © 2019 by the authors.
Source Title: Molecules
ISSN: 14203049
DOI: 10.3390/molecules24173127
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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