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Title: Human Ageing Genomic Resources: New and updated databases
Authors: Tacutu, R.
Thornton, D.
Johnson, E.
Budovsky, A.
Barardo, D. 
Craig, T.
DIana, E.
Lehmann, G.
Toren, D.
Wang, J.
Fraifeld, V.E.
De Magalhães, J.P.
Issue Date: 2018
Publisher: Oxford University Press
Citation: Tacutu, R., Thornton, D., Johnson, E., Budovsky, A., Barardo, D., Craig, T., DIana, E., Lehmann, G., Toren, D., Wang, J., Fraifeld, V.E., De Magalhães, J.P. (2018). Human Ageing Genomic Resources: New and updated databases. Nucleic Acids Research 46 (D1) : D1083-D1090. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial 4.0 International
Abstract: In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR's main functionalities, highlighting new additions and improvements. HAGR consists of six core databases: (i) the GenAge database of ageing-related genes, in turn composed of a dataset of >300 human ageing-related genes and a dataset with >2000 genes associated with ageing or longevity in model organisms; (ii) the AnAge database of animal ageing and longevity, featuring >4000 species; (iii) the GenDR database with >200 genes associated with the life-extending effects of dietary restriction; (iv) the LongevityMap database of human genetic association studies of longevity with >500 entries; (v) the DrugAge database with >400 ageing or longevity-associated drugs or compounds; (vi) the CellAge database with >200 genes associated with cell senescence. All our databases are manually curated by experts and regularly updated to ensure a high quality data. Cross-links across our databases and to external resources help researchers locate and integrate relevant information. HAGR is freely available online ( © 2017 The Author(s).
Source Title: Nucleic Acids Research
ISSN: 03051048
DOI: 10.1093/nar/gkx1042
Rights: Attribution-NonCommercial 4.0 International
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