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Title: Molecular mechanisms of action of tocotrienols in cancer: Recent trends and advancements
Authors: Aggarwal, V.
Kashyap, D.
Sak, K.
Tuli, H.S.
Jain, A.
Chaudhary, A.
Garg, V.K.
Sethi, G. 
Yerer, M.B.
Keywords: Anti-angiogenesis
Issue Date: 2019
Publisher: MDPI AG
Citation: Aggarwal, V., Kashyap, D., Sak, K., Tuli, H.S., Jain, A., Chaudhary, A., Garg, V.K., Sethi, G., Yerer, M.B. (2019). Molecular mechanisms of action of tocotrienols in cancer: Recent trends and advancements. International Journal of Molecular Sciences 20 (3) : 656. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Tocotrienols, found in several natural sources such as rice bran, annatto seeds, and palm oil have been reported to exert various beneficial health promoting properties especially against chronic diseases, including cancer. The incidence of cancer is rapidly increasing around the world not only because of continual aging and growth in global population, but also due to the adaptation of Western lifestyle behaviours, including intake of high fat diets and low physical activity. Tocotrienols can suppress the growth of different malignancies, including those of breast, lung, ovary, prostate, liver, brain, colon, myeloma, and pancreas. These findings, together with the reported safety profile of tocotrienols in healthy human volunteers, encourage further studies on the potential application of these compounds in cancer prevention and treatment. In the current article, detailed information about the potential molecular mechanisms of actions of tocotrienols in different cancer models has been presented and the possible effects of these vitamin E analogues on various important cancer hallmarks, i.e., cellular proliferation, apoptosis, angiogenesis, metastasis, and inflammation have been briefly analyzed. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
ISSN: 16616596
DOI: 10.3390/ijms20030656
Rights: Attribution 4.0 International
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