Please use this identifier to cite or link to this item: https://doi.org/10.3390/molecules24061047
Title: Role of natural products in modulating histone deacetylases in cancer
Authors: Merarchi, M.
Sethi, G. 
Shanmugam, M.K. 
Fan, L. 
Arfuso, F.
Ahn, K.S.
Keywords: Cancer
HDACs
Metastasis
Natural products
Proliferation
Issue Date: 2019
Publisher: MDPI AG
Citation: Merarchi, M., Sethi, G., Shanmugam, M.K., Fan, L., Arfuso, F., Ahn, K.S. (2019). Role of natural products in modulating histone deacetylases in cancer. Molecules 24 (6) : 1047. ScholarBank@NUS Repository. https://doi.org/10.3390/molecules24061047
Rights: Attribution 4.0 International
Abstract: Histone deacetylases (HDACs) are enzymes that can control transcription by modifying chromatin conformation, molecular interactions between the DNA and the proteins as well as the histone tail, through the catalysis of the acetyl functional sites removal of proteins from the lysine residues. Also, HDACs have been implicated in the post transcriptional process through the regulation of the proteins acetylation, and it has been found that HDAC inhibitors (HDACi) constitute a promising class of pharmacological drugs to treat various chronic diseases, including cancer. Indeed, it has been demonstrated that in several cancers, elevated HDAC enzyme activities may be associated with aberrant proliferation, survival and metastasis. Hence, the discovery and development of novel HDACi from natural products, which are known to affect the activation of various oncogenic molecules, has attracted significant attention over the last decade. This review will briefly emphasize the potential of natural products in modifying HDAC activity and thereby attenuating initiation, progression and promotion of tumors. © 2019 by the authors.
Source Title: Molecules
URI: https://scholarbank.nus.edu.sg/handle/10635/210793
ISSN: 14203049
DOI: 10.3390/molecules24061047
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3390_molecules24061047.pdf448.88 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

42
checked on Feb 3, 2023

Page view(s)

89
checked on Feb 2, 2023

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons