Please use this identifier to cite or link to this item: https://doi.org/10.1186/s13045-019-0814-6
Title: EZH2 abnormalities in lymphoid malignancies: Underlying mechanisms and therapeutic implications
Authors: Li, B. 
Chng, W.-J. 
Keywords: B cell
EBV
EZH2
EZH2 inhibitor
Lymphoid malignancies
Lymphoma
T cell
Issue Date: 2019
Publisher: BioMed Central Ltd.
Citation: Li, B., Chng, W.-J. (2019). EZH2 abnormalities in lymphoid malignancies: Underlying mechanisms and therapeutic implications. Journal of Hematology and Oncology 12 (1) : 118. ScholarBank@NUS Repository. https://doi.org/10.1186/s13045-019-0814-6
Rights: Attribution 4.0 International
Abstract: EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which along with other PRC2 components mediates gene expression suppression via the methylation of Histone H3 at lysine 27. Recent studies have revealed a dichotomous role of EZH2 in physiology and in the pathogenesis of cancer. While it plays an essential role in the development of the lymphoid system, its deregulation, whether due to genetic or non-genetic causes, promotes B cell-and T cell-related lymphoma or leukemia. These findings triggered a boom in the development of therapeutic EZH2 inhibitors in recent years. Here, we discuss physiologic and pathogenic function of EZH2 in lymphoid context, various internal causes of EZH2 aberrance and how EZH2 modulates lymphomagenesis through epigenetic silencing, post-translational modifications (PTMs), orchestrating with surrounding tumor micro-environment and associating with RNA or viral partners. We also summarize different strategies to directly inhibit PRC2-EZH2 or to intervene EZH2 upstream signaling. © 2019 The Author(s).
Source Title: Journal of Hematology and Oncology
URI: https://scholarbank.nus.edu.sg/handle/10635/210718
ISSN: 17568722
DOI: 10.1186/s13045-019-0814-6
Rights: Attribution 4.0 International
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