Please use this identifier to cite or link to this item:
Title: Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations
Authors: Teo, W.-Y.
Sekar, K.
Seshachalam, P.
Shen, J.
Chow, W.-Y.
Lau, C.C.
Yang, H.K.
Park, J.
Kang, S.-G.
Li, X.
Nam, D.-H.
Hui, K.M. 
Issue Date: 2019
Publisher: Nature Publishing Group
Citation: Teo, W.-Y., Sekar, K., Seshachalam, P., Shen, J., Chow, W.-Y., Lau, C.C., Yang, H.K., Park, J., Kang, S.-G., Li, X., Nam, D.-H., Hui, K.M. (2019). Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations. Scientific Reports 9 (1) : 7442. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Glioblastoma multiforme (GBM), a deadly cancer, is the most lethal and common malignant brain tumor, and the leading cause of death in adult brain tumors. While genomic data continues to rocket, clinical application and translation to patient care are lagging behind. Big data now deposited in the TCGA network offers a window to generate novel clinical hypotheses. We hypothesized that a TCGA-derived gene-classifier can be applied across different gene profiling platforms and population groups. This gene-classifier validated three robust GBM-subtypes across six different platforms, among Caucasian, Korean and Chinese populations: Three Caucasian-predominant TCGA-cohorts (Affymetrix U133A = 548, Agilent Custom-Array = 588, RNA-seq = 168), and three Asian-cohorts (Affymetrix Human Gene 1.0ST-Array = 61, Illumina = 52, Agilent 4 × 44 K = 60). To understand subtype-relevance in patient therapy, we investigated retrospective TCGA patient clinical sets. Subtype-specific patient survival outcome was similarly poor and reflected the net result of a mixture of treatment regimens with/without surgical resection. As a proof-of-concept, in subtype-specific patient-derived orthotopic xenograft (PDOX) mice, Classical-subtype demonstrated no survival difference comparing radiation-therapy versus temozolomide monotherapies. Though preliminary, a PDOX model of Proneural/Neural-subtype demonstrated significantly improved survival with temozolomide compared to radiation-therapy. A larger scale study using this gene-classifier may be useful in clinical outcome prediction and patient selection for trials based on subtyping. © 2019, The Author(s).
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/s41598-019-43173-y
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_s41598-019-43173-y.pdf2.98 MBAdobe PDF



Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons