Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-018-03612-2
Title: Pharmaceutical concentration using organic solvent forward osmosis for solvent recovery
Authors: Cui, Y. 
Chung, T.-S. 
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Cui, Y., Chung, T.-S. (2018). Pharmaceutical concentration using organic solvent forward osmosis for solvent recovery. Nature Communications 9 (1) : 1426. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-03612-2
Rights: Attribution 4.0 International
Abstract: The organic solvent forward osmosis (OSFO) process can simultaneously concentrate the active pharmaceutical ingredients (APIs) and recover the organic solvents. Here we demonstrate and evaluate an OSFO process for solvent recovery. In this demonstration, OSFO was conducted in different solvents with different draw solutes. The OSFO process shows rejections >98% when recovering organic solvents from different feed solutions, even when the feed concentration is as high as 20 wt%. More importantly, all systems exhibit relatively low ratios of reverse solute flux to solvent flux, indicating that the adverse effects of using hazardous draw solutions could be minimized. Nevertheless, the use of non-hazardous draw solutes such as citric acid is highly recommended to remove any potential risk, and it has been demonstrated. Herein, the OSFO process is a promising technology for solvent recovery as it possesses a reasonable solvent flux, low reverse solute flux and requires no external pressure. © 2018 The Author(s).
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/210076
ISSN: 2041-1723
DOI: 10.1038/s41467-018-03612-2
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_s41467-018-03612-2.pdf489.52 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

74
checked on Sep 30, 2022

Page view(s)

57
checked on Sep 29, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons