Please use this identifier to cite or link to this item: https://doi.org/10.3390/biomedicines7030053
Title: A brief overview of the antitumoral actions of leelamine
Authors: Merarchi, M.
Jung, Y.Y.
Fan, L. 
Sethi, G. 
Ahn, K.S.
Keywords: Leelamine
Malignancies
Molecular mechanisms
Preclinical models
Issue Date: 2019
Publisher: MDPI AG
Citation: Merarchi, M., Jung, Y.Y., Fan, L., Sethi, G., Ahn, K.S. (2019). A brief overview of the antitumoral actions of leelamine. Biomedicines 7 (3) : 53. ScholarBank@NUS Repository. https://doi.org/10.3390/biomedicines7030053
Rights: Attribution 4.0 International
Abstract: For the last couple of decades, natural products, either applied singly or in conjunction with other cancer therapies including chemotherapy and radiotherapy, have allowed us to combat different types of human cancers through the inhibition of their initiation and progression. The principal sources of these useful compounds are isolated from plants that were described in traditional medicines for their curative potential. Leelamine, derived from the bark of pine trees, was previously reported as having a weak agonistic effect on cannabinoid receptors and limited inhibitory effects on pyruvate dehydrogenase kinases (PDKs). It has been reported to possess a strong lysosomotropic property; this feature enables its assembly inside the acidic compartments within a cell, such as lysosomes, which may eventually hinder endocytosis. In this review, we briefly highlight the varied antineoplastic actions of leelamine that have found implications in pharmacological research, and the numerous intracellular targets affected by this agent that can effectively negate the oncogenic process. © 2019 by the authors.
Source Title: Biomedicines
URI: https://scholarbank.nus.edu.sg/handle/10635/209941
ISSN: 2227-9059
DOI: 10.3390/biomedicines7030053
Rights: Attribution 4.0 International
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