Please use this identifier to cite or link to this item: https://doi.org/10.1001/jamanetworkopen.2019.11970
Title: Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China
Authors: Seow, W.J. 
Shu, X.-O.
Nicholson, J.K.
Holmes, E.
Walker, D.I.
Hu, W.
Cai, Q.
Gao, Y.-T.
Xiang, Y.-B.
Moore, S.C.
Bassig, B.A.
Wong, J.Y.Y.
Zhang, J.
Ji, B.-T.
Boulangé, C.L.
Kaluarachchi, M.
Wijeyesekera, A.
Zheng, W.
Elliott, P.
Rothman, N.
Lan, Q.
Issue Date: 2019
Publisher: NLM (Medline)
Citation: Seow, W.J., Shu, X.-O., Nicholson, J.K., Holmes, E., Walker, D.I., Hu, W., Cai, Q., Gao, Y.-T., Xiang, Y.-B., Moore, S.C., Bassig, B.A., Wong, J.Y.Y., Zhang, J., Ji, B.-T., Boulangé, C.L., Kaluarachchi, M., Wijeyesekera, A., Zheng, W., Elliott, P., Rothman, N., Lan, Q. (2019). Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China. JAMA network open 2 (9) : e1911970. ScholarBank@NUS Repository. https://doi.org/10.1001/jamanetworkopen.2019.11970
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Importance: Chinese women have the highest rate of lung cancer among female never-smokers in the world, and the etiology is poorly understood. Objective: To assess the association between metabolomics and lung cancer risk among never-smoking women. Design, Setting, and Participants: This nested case-control study included 275 never-smoking female patients with lung cancer and 289 never-smoking cancer-free control participants from the prospective Shanghai Women's Health Study recruited from December 28, 1996, to May 23, 2000. Validated food frequency questionnaires were used for the collection of dietary information. Metabolomic analysis was conducted from November 13, 2015, to January 6, 2016. Data analysis was conducted from January 6, 2016, to November 29, 2018. Exposures: Untargeted ultra-high-performance liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance metabolomic profiles were characterized using prediagnosis urine samples. A total of 39?416 metabolites were measured. Main Outcomes and Measures: Incident lung cancer. Results: Among the 564 women, those who developed lung cancer (275 participants; median [interquartile range] age, 61.0 [52-65] years) and those who did not develop lung cancer (289 participants; median [interquartile range] age, 62.0 [53-66] years) at follow-up (median [interquartile range] follow-up, 10.9 [9.0-11.7] years) were similar in terms of their secondhand smoke exposure, history of respiratory diseases, and body mass index. A peak metabolite, identified as 5-methyl-2-furoic acid, was significantly associated with lower lung cancer risk (odds ratio, 0.57 [95% CI, 0.46-0.72]; P?
Source Title: JAMA network open
URI: https://scholarbank.nus.edu.sg/handle/10635/209938
ISSN: 2574-3805
DOI: 10.1001/jamanetworkopen.2019.11970
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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