Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijerph16203922
Title: Effect of native and acetylated dietary resistant starches on intestinal fermentative capacity of normal and stunted children in Southern India
Authors: Balamurugan, R.
Pugazhendhi, S.
Balachander, G.M. 
Dharmalingam, T.
Mortimer, E.K.
Gopalsamy, G.L.
Woodman, R.J.
Meng, R.
Alpers, D.H.
Manary, M.
Binder, H.J.
Brown, I.L.
Young, G.P.
Ramakrishna, B.S.
Keywords: Colonic microbiota
Dysbiosis
Gut microbiota
Human health
Prebiotic
Resistant starch
Therapeutic strategies
Issue Date: 2019
Publisher: MDPI AG
Citation: Balamurugan, R., Pugazhendhi, S., Balachander, G.M., Dharmalingam, T., Mortimer, E.K., Gopalsamy, G.L., Woodman, R.J., Meng, R., Alpers, D.H., Manary, M., Binder, H.J., Brown, I.L., Young, G.P., Ramakrishna, B.S. (2019). Effect of native and acetylated dietary resistant starches on intestinal fermentative capacity of normal and stunted children in Southern India. International Journal of Environmental Research and Public Health 16 (20) : 3922. ScholarBank@NUS Repository. https://doi.org/10.3390/ijerph16203922
Rights: Attribution 4.0 International
Abstract: The health benefits of dietary amylase resistant starch (RS) arise from intestinal microbial fermentation and generation of short chain fatty acids (SCFA). We compared the intestinal fermentative capability of stunted and nonstunted (‘healthy’) children in southern India using two types of RS: high amylose maize starch (HAMS) and acetylated HAMS (HAMSA). Twenty children (10 stunted and 10 healthy) aged 2 to 5 years were fed biscuits containing HAMS (10 g/day) for two weeks followed by a 2-week washout and then HAMSA biscuits (10 g/day) for 2 weeks. Fecal samples were collected at 3-4 day intervals and pH and SCFA analyzed. At entry, stunted children had lower SCFA concentrations compared to healthy children. Both types of RS led to a significant decrease in fecal pH and increase in fecal acetate and propionate in both healthy and stunted children. However, while HAMS increased fecal butyrate in both groups of children, HAMSA increased butyrate in healthy but not stunted children. Furthermore, healthy children showed a significantly greater increase than stunted children in both acetate and butyrate when fed either RS. No adverse effects were reported with either RS. Stunted children have impaired capacity to ferment certain types of RS which has implications for choice of RS in formulations aimed at improving microbial function in stunted children. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Environmental Research and Public Health
URI: https://scholarbank.nus.edu.sg/handle/10635/209929
ISSN: 1661-7827
DOI: 10.3390/ijerph16203922
Rights: Attribution 4.0 International
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