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Title: Dissection of gastric cancer heterogeneity for precision oncology
Authors: Ho, S.W.T.
Tan, P. 
Keywords: gastric cancer
molecular classification
translational research
tumor heterogeneity
tumor microenvironment
Issue Date: 2019
Publisher: Blackwell Publishing Ltd
Citation: Ho, S.W.T., Tan, P. (2019). Dissection of gastric cancer heterogeneity for precision oncology. Cancer Science 110 (11) : 3405-3414. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Gastric cancer (GC) remains the fifth most prevalent cancer worldwide and the third leading cause of global cancer mortality. Comprehensive -omic studies have unveiled a heterogeneous GC landscape, with considerable molecular diversity both between and within tumors. Given the complex nature of GC, a long-sought goal includes effective identification of distinct patient subsets with prognostic and/or predictive outcomes to enable tailoring of specific treatments (“precision oncology”). In this review, we highlight various approaches to molecular classification in GC, covering recent genomic, transcriptomic, proteomic and epigenomic features. We pay special attention to the translational significance of classifier systems and examine potential confounding factors which deserve further investigation. In particular, we discuss recent advancements in our knowledge of intra-subtype, intra-patient and intra-tumor heterogeneity, and the pivotal role of the tumor stromal microenvironment. © 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
Source Title: Cancer Science
ISSN: 1347-9032
DOI: 10.1111/cas.14191
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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