Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jsps.2019.09.005
Title: Lidocaine loaded gelatin/gelatinized tapioca starch films for buccal delivery and the irritancy evaluation using chick chorioallantoic membrane
Authors: Wannaphatchaiyong, S.
Heng, P.W.S. 
Suksaeree, J.
Boonme, P.
Pichayakorn, W.
Keywords: Buccal film
Chick chorioallantoic membrane
Gelatin
Gelatinized tapioca starch
Issue Date: 2019
Publisher: Elsevier B.V.
Citation: Wannaphatchaiyong, S., Heng, P.W.S., Suksaeree, J., Boonme, P., Pichayakorn, W. (2019). Lidocaine loaded gelatin/gelatinized tapioca starch films for buccal delivery and the irritancy evaluation using chick chorioallantoic membrane. Saudi Pharmaceutical Journal 27 (8) : 1085-1095. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jsps.2019.09.005
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: The aim of this study was to confirm the feasibility of gelatin/gelatinized tapioca starch (? st) films for buccal delivery and to evaluate their irritancy. Lidocaine (LB) and lidocaine hydrochloride (LH) were used as model drugs and glycerin was used as the plasticizer. The scanning electron microscopy, atomic force electron microscopy, X-ray diffraction and thermogravimetric analysis results confirmed the compatibility of gelatin/? st/glycerin (G?gly) films. Drug releases of LB- or LH-G?gly films were evaluated. The drug release profiles of medicated films presented good patterns in both short time and 8 h drug release studies. The permeation study was examined through chick chorioallantoic membrane (CAM) by using modified Franz diffusion cells. Moreover, the irritancy study for buccal films was also examined by a hen's egg test on CAM model (HET-CAM). The results revealed that LB and LH could permeate through CAM, and these G?gly films created no irritation on HET-CAM. This indicates that the LB- and LH-G?gly films are possible to use as buccal films. © 2019 The Authors
Source Title: Saudi Pharmaceutical Journal
URI: https://scholarbank.nus.edu.sg/handle/10635/209894
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2019.09.005
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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