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|Title:||Long-term prognostic significance of interleukin-17-producing T cells in patients with non-small cell lung cancer||Authors:||Song, L.
|Issue Date:||2019||Publisher:||Blackwell Publishing Ltd||Citation:||Song, L., Ma, S., Chen, L., Miao, L., Tao, M., Liu, H. (2019). Long-term prognostic significance of interleukin-17-producing T cells in patients with non-small cell lung cancer. Cancer Science 110 (7) : 2100-2109. ScholarBank@NUS Repository. https://doi.org/10.1111/cas.14068||Rights:||Attribution-NonCommercial-NoDerivatives 4.0 International||Abstract:||The presence of interleukin (IL)-17-producing T cells has recently been reported in non-small cell lung cancer (NSCLC) patients. However, the long-term prognostic significance of these populations in NSCLC patients remains unknown. In the present study, we collected peripheral blood from 82 NSCLC patients and 22 normal healthy donors (NC). Percentages of IL-17-producing CD4+T (Th17), CD8+T (Tc17) and ??T cells (??T17) were measured to determine their association with clinical outcomes and overall survival (OS) in NSCLC. All NSCLC patients were followed up until July 2018. Median follow-up time was 13.5 months (range 1-87 months). The 3- and 5-year survival rate was 27% and 19.6%, respectively. We found that Th17 cells and ??T17 cells were significantly increased, whereas Tc17 cells were markedly decreased in patients with NSCLC compared with those in NC. In addition, Th17 cells were significantly positively associated with T helper type 1 cells (Th1), whereas ??T17 cells were significantly negatively associated with ??T + interferon (IFN)-?+ cells. High percentages of peripheral Tc17 cells were significantly associated with favorable 5-year OS (P =.025), especially in patients with early TNM stage (P =.016). Furthermore, high percentages of peripheral Th17 cells were positively associated with favorable 5-year OS in patients with late TNM stage (P =.002). However, no significant association was observed between ??T17 cells and OS, regardless of the TNM stage. In conclusion, our findings suggest that enhanced Th17 and reduced Tc17 cells in the peripheral blood could be a significant predictor of a favorable prognosis for NSCLC patients. © 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.||Source Title:||Cancer Science||URI:||https://scholarbank.nus.edu.sg/handle/10635/209567||ISSN:||1347-9032||DOI:||10.1111/cas.14068||Rights:||Attribution-NonCommercial-NoDerivatives 4.0 International|
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