Please use this identifier to cite or link to this item: https://doi.org/10.3390/cells8101158
Title: Nanoparticles Targeting STATs in Cancer Therapy
Authors: Ashrafizadeh, M.
Ahmadi, Z.
Kotla, N.G.
Afshar, E.G.
Samarghandian, S.
Mandegary, A.
Pardakhty, A.
Mohammadinejad, R.
Sethi, G. 
Keywords: bioavailability
cancer therapy
drug delivery
nanoparticle
STAT3
Issue Date: 2019
Publisher: NLM (Medline)
Citation: Ashrafizadeh, M., Ahmadi, Z., Kotla, N.G., Afshar, E.G., Samarghandian, S., Mandegary, A., Pardakhty, A., Mohammadinejad, R., Sethi, G. (2019). Nanoparticles Targeting STATs in Cancer Therapy. Cells 8 (10) : 1158. ScholarBank@NUS Repository. https://doi.org/10.3390/cells8101158
Rights: Attribution 4.0 International
Abstract: Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signaling pathways involved in cancer initiation and metastasis. It has been shown that signal transducers and activator of transcription (STAT) contributes to the progression of cancer cells. This important signaling pathway is associated with a number of biological processes including cell cycle, differentiation, proliferation and apoptosis. It appears that dysregulation of the STAT signaling pathway promotes the migration, viability and malignancy of various tumor cells. Hence, there have been many attempts to target the STAT signaling pathway. However, it seems that currently applied therapeutics may not be able to effectively modulate the STAT signaling pathway and suffer from a variety of drawbacks such as low bioavailability and lack of specific tumor targeting. In the present review, we demonstrate how nanocarriers can be successfully applied for encapsulation of STAT modulators in cancer therapy.
Source Title: Cells
URI: https://scholarbank.nus.edu.sg/handle/10635/209549
ISSN: 2073-4409
DOI: 10.3390/cells8101158
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3390_cells8101158.pdf601.79 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

45
checked on Jan 25, 2023

Page view(s)

78
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons