Please use this identifier to cite or link to this item: https://doi.org/10.47102/annals-acadmedsg.2021160
Title: Safety and side effect profile of Pfizer-BioNTech COVID-19 vaccination among healthcare workers: A tertiary hospital experience in Singapore
Authors: Lim, SM
Chan, HC
Santosa, A
Quek, SC 
Liu, EHC 
Somani, J
Keywords: COVID-19
COVID-19 Vaccines
Cross-Sectional Studies
Health Personnel
Humans
SARS-CoV-2
Singapore
Tertiary Care Centers
Vaccination
Issue Date: 1-Sep-2021
Publisher: Academy of Medicine, Singapore
Citation: Lim, SM, Chan, HC, Santosa, A, Quek, SC, Liu, EHC, Somani, J (2021-09-01). Safety and side effect profile of Pfizer-BioNTech COVID-19 vaccination among healthcare workers: A tertiary hospital experience in Singapore. Annals of the Academy of Medicine, Singapore 50 (9) : 703-711. ScholarBank@NUS Repository. https://doi.org/10.47102/annals-acadmedsg.2021160
Abstract: INTRODUCTION: Vaccination remains a key strategy to living endemically with COVID-19. The Pfizer-BioNTech COVID-19 vaccine was first granted interim authorisation for use in Singapore in December 2020. With overseas studies published about the safety and side effect profiles of mRNA COVID-19 vaccines focusing mainly on non-Asian populations, we described the side effects of Pfizer-BioNTech COVID-19 vaccination experienced by the healthcare workers (HCWs) in a tertiary hospital in Singapore. METHODS: Data were obtained from the Occupational Health Clinic (OHC) at the National University Hospital in Singapore, which monitored staff for any adverse effects within 30 minutes post vaccination on-site and any adverse effects after that. A cross-sectional study among the vaccinated HCWs was conducted using an online survey, which established basic demographics, histories of allergies or atopic disorders, and adverse events encountered after dose 1 and dose 2 of vaccination. RESULTS: No anaphylaxis was reported. Most common symptom was giddiness (32.7%) experienced by HCWs within 30 minutes. Adverse events attended post-vaccination by OHC were generally mild and self-limiting. From the survey, odds of experiencing an adverse event after dose 2 was significantly higher than after the first dose, especially for fever/chills (odds ratio [OR] 22.5). Fever/chills, injection site reactions, headache, aches and pains, and feeling unwell were significantly more common in HCWs below 60 years compared to those ≥60 years. An allergy to food (adjusted OR 2.7) and a history of eczema/sensitive skin (adjusted OR 2.6) were associated with a skin reaction not at injection site. CONCLUSION: The side effects experienced after Pfizer-BioNTech COVID-19 vaccines are generally self-limiting and mild, with no anaphylaxis reported.
Source Title: Annals of the Academy of Medicine, Singapore
URI: https://scholarbank.nus.edu.sg/handle/10635/208942
ISSN: 03044602
DOI: 10.47102/annals-acadmedsg.2021160
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Safety and side effect profile of Pfizer-BioNTech COVID-19 vaccination among healthcare workers A tertiary hospital experience in Singapore.pdfPublished version424.18 kBAdobe PDF

CLOSED

None

SCOPUSTM   
Citations

6
checked on Feb 3, 2023

Page view(s)

109
checked on Feb 2, 2023

Download(s)

2
checked on Feb 2, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.