Please use this identifier to cite or link to this item: https://doi.org/10.11622/smedj.2016060
Title: Eosinophilic oesophagitis in children: an uncommon occurrence in a predominantly Chinese population in Singapore
Authors: TAN LI NIEN 
Srivastava, S. 
Teh, Ming
Quak, S.H. 
Aw, Marion M
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
biopsies
children
eosinophilic oesophagitis
oesophagogastroduodenoscopy
ENDOSCOPIC FEATURES
CONSENSUS RECOMMENDATIONS
CELIAC-DISEASE
PREVALENCE
ADULTS
EXPERIENCE
BIOPSY
Issue Date: 1-Apr-2017
Publisher: SINGAPORE MEDICAL ASSOC
Citation: TAN LI NIEN, Srivastava, S., Teh, Ming, Quak, S.H., Aw, Marion M (2017-04-01). Eosinophilic oesophagitis in children: an uncommon occurrence in a predominantly Chinese population in Singapore. SINGAPORE MEDICAL JOURNAL 58 (4) : 218-222. ScholarBank@NUS Repository. https://doi.org/10.11622/smedj.2016060
Abstract: INTRODUCTION We aimed to determine the prevalence and clinical manifestations of eosinophilic oesophagitis (EoE) in children who presented to a tertiary care hospital in Singapore. METHODS We conducted a retrospective review of all oesophageal biopsies taken during oesophagogastroduodenoscopy (OGD) from March 2010 to December 2011. The patients’ demographics and clinical characteristics were collected. Biopsies were reviewed by a single pathologist who was blinded to the original reports, using the current consensus criteria for the histological diagnosis of EoE. RESULTS Of the 88 children who had biopsies during OGD, 4 (4.5%) children (three boys, one girl; three Chinese, one Caucasian) were diagnosed with EoE. Their median age was 9.5 (range 4.0–12.0) years. The main clinical presentations were abdominal pain (in the three older children) and vomiting (in the youngest child). Three children had a history of atopy. Three children were diagnosed with EoE in the original histology reports, while one was diagnosed after the second review following histology demonstrating > 15 eosinophil granulocytes per high power field and microabscess formation. Endoscopy findings revealed oesophagitis in two children, one of whom was already on acid suppression therapy. Although three children were started on acid suppression therapy, they continued to be symptomatic. One child was also treated with swallowed fluticasone and two with food allergen avoidance, resulting in symptom improvement. CONCLUSION Although EoE is uncommon in Singapore, greater awareness is needed among family physicians and general paediatricians. Paediatric gastroenterologists should alert pathologists when sending biopsy specimens that are suspicious for EoE.
Source Title: SINGAPORE MEDICAL JOURNAL
URI: https://scholarbank.nus.edu.sg/handle/10635/208669
ISSN: 0037-5675
DOI: 10.11622/smedj.2016060
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