Please use this identifier to cite or link to this item: https://doi.org/10.1002/adma.202100012
Title: Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID-19 Cytokine Storm
Authors: Meng, Qian-Fang
Tian, Rui 
Long, Haiyi
Wu, Xianjia
Lai, Jialin
Zharkova, Olga 
Wang, Jiong-Wei 
Chen, Xiaoyuan 
Rao, Lang
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
biomaterials
COVID-19
cytokine release syndrome
cytokine storm
nanoparticles
SARS-CoV-2
ANTI-TNF-ALPHA
POLYMERIC NANOPARTICLES
VIRAL-INFECTION
DELIVERY
ACTIVATION
PNEUMONIA
INFLAMMATION
CORONAVIRUS
CONJUGATION
CHEMOKINE
Issue Date: 10-Apr-2021
Publisher: WILEY-V C H VERLAG GMBH
Citation: Meng, Qian-Fang, Tian, Rui, Long, Haiyi, Wu, Xianjia, Lai, Jialin, Zharkova, Olga, Wang, Jiong-Wei, Chen, Xiaoyuan, Rao, Lang (2021-04-10). Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID-19 Cytokine Storm. ADVANCED MATERIALS 33 (20). ScholarBank@NUS Repository. https://doi.org/10.1002/adma.202100012
Abstract: The COVID-19 pandemic, induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused great impact on the global economy and people's daily life. In the clinic, most patients with COVID-19 show none or mild symptoms, while approximately 20% of them develop severe pneumonia, multiple organ failure, or septic shock due to infection-induced cytokine release syndrome (the so-called “cytokine storm”). Neutralizing antibodies targeting inflammatory cytokines may potentially curb immunopathology caused by COVID-19; however, the complexity of cytokine interactions and the multiplicity of cytokine targets make attenuating the cytokine storm challenging. Nonspecific in vivo biodistribution and dose-limiting side effects further limit the broad application of those free antibodies. Recent advances in biomaterials and nanotechnology have offered many promising opportunities for infectious and inflammatory diseases. Here, potential mechanisms of COVID-19 cytokine storm are first discussed, and relevant therapeutic strategies and ongoing clinical trials are then reviewed. Furthermore, recent research involving emerging biomaterials for improving antibody-based and broad-spectrum cytokine neutralization is summarized. It is anticipated that this work will provide insights on the development of novel therapeutics toward efficacious management of COVID-19 cytokine storm and other inflammatory diseases.
Source Title: ADVANCED MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/208417
ISSN: 09359648
15214095
DOI: 10.1002/adma.202100012
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