Please use this identifier to cite or link to this item: https://doi.org/10.1142/S1758825118500357
Title: Association of Hemodynamic Behavior in the Thoracic Aortic Aneurysm to the Intraluminal Thrombus Prediction: A Two-Way Fluid Structure Coupling Investigation
Authors: Ong, Chi Wei 
Yap, Choon Hwai
Kabinejadian, Foad 
Yen, Ngoc Nguyen
Cui, Fangsen
Chua, Kian Jon 
Ho, Pei 
Leo, Hwa Liang 
Keywords: Science & Technology
Technology
Mechanics
Intraluminal thrombus
thoracic aortic aneurysm
fluid structure interaction
vortex
OSI
WALL SHEAR-STRESS
BLOOD-FLOW
PULSATILE FLOW
PLATELET-AGGREGATION
NUMERICAL-SIMULATION
DEPOSITION
EXPANSION
DYNAMICS
ATHEROSCLEROSIS
PATTERNS
Issue Date: 1-May-2018
Publisher: IMPERIAL COLLEGE PRESS
Citation: Ong, Chi Wei, Yap, Choon Hwai, Kabinejadian, Foad, Yen, Ngoc Nguyen, Cui, Fangsen, Chua, Kian Jon, Ho, Pei, Leo, Hwa Liang (2018-05-01). Association of Hemodynamic Behavior in the Thoracic Aortic Aneurysm to the Intraluminal Thrombus Prediction: A Two-Way Fluid Structure Coupling Investigation. INTERNATIONAL JOURNAL OF APPLIED MECHANICS 10 (4). ScholarBank@NUS Repository. https://doi.org/10.1142/S1758825118500357
Abstract: Clotting of blood elements or intraluminal thrombus (ILT) is known to develop within aortic aneurysm sacs, and is clinically associated with the dilation and rupturing of aneurysms. However, the underlying factors that generate ILT are still unclear. We hypothesize that ILT can form under the influence of unfavorable hemodynamic patterns. This paper presents evidence for one such type of flow dynamics that could give rise to ILT within the aneurysm sac. Image-based patient-specific fluid-structure-interaction modeling of three cases of thoracic aortic aneurysms was performed, using retrospective CT images to investigate the formation of ILT as a result of local hemodynamic of aneurysm. This study showed that the formation of the ILT was associated with a vortex observed near the aortic narrowing, upstream of the aneurysm sac. This vortex could subject the blood elements to elevated stresses before directing them into the sac. The recirculation flow within the aneurysm sac may trap these activated blood elements, thus, leading to the formation of ILT during early diastole. One primary cause for ILT, as indicated in this study, could be attributed to the sharp curvature at the aortic narrowing (or isthmus) that gives rise to the vortex. Our study also showed that the size and location of the aneurysm have a direct impact on the duration and location of the vortex, which could influence the formation of the ILT.
Source Title: INTERNATIONAL JOURNAL OF APPLIED MECHANICS
URI: https://scholarbank.nus.edu.sg/handle/10635/207136
ISSN: 17588251
1758826X
DOI: 10.1142/S1758825118500357
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