Please use this identifier to cite or link to this item: https://doi.org/10.29252/jafm.12.06.29769
Title: Pulsatile Flow Investigation in Development of Thoracic Aortic Aneurysm: An In-Vitro Validated Fluid Structure Interaction Analysis
Authors: Ong, CW 
Kabinejadian, F 
Xiong, F 
Wong, YR
Toma, M
Nguyen, YN
Chua, KJ
Cui, FS
Ho, P 
Leo, H 
Keywords: Science & Technology
Physical Sciences
Technology
Thermodynamics
Mechanics
Thoracic aortic aneurysm
Particle image velocimetry
Thrombus
Fluid structure interaction (FSI)
Hemodynamics
BLOOD-FLOW
INTRALUMINAL THROMBUS
NUMERICAL-SIMULATION
COMPUTATIONAL MODEL
MEMBRANE DESIGN
COVERED STENT
SHEAR-STRESS
WALL STRESS
DYNAMICS
HEMODYNAMICS
Issue Date: 1-Nov-2019
Publisher: ISFAHAN UNIV TECHNOLOGY
Citation: Ong, CW, Kabinejadian, F, Xiong, F, Wong, YR, Toma, M, Nguyen, YN, Chua, KJ, Cui, FS, Ho, P, Leo, H (2019-11-01). Pulsatile Flow Investigation in Development of Thoracic Aortic Aneurysm: An In-Vitro Validated Fluid Structure Interaction Analysis. JOURNAL OF APPLIED FLUID MECHANICS 12 (6) : 1855-1872. ScholarBank@NUS Repository. https://doi.org/10.29252/jafm.12.06.29769
Abstract: Thoracic aortic aneurysm (TAA) is a severe cardiovascular disease with a high mortality rate, if left untreated. Clinical observations show that aneurysm growth can be linked to undesirable hemodynamic conditions of the aortic aneurysm. In order to gain more insight on TAA formation, we developed a computational framework in vitro to investigate and compare the flow patterns between pre-aneurismal and post-aneurismal aorta using a deformable wall model. This numerical framework was validated by an in vitro experiment accounting for the patient-specific geometrical features and the physiological conditions. The complex flow behaviors in the pre-aneurismal and post-aneurismal aorta were evaluated experimentally by particle image velocimetry (PIV). Our experimental results demonstrated flow behaviors similar to those observed in the fluid-structure interaction (FSI) numerical study. We observed a small vortex induced by the non-planarity of pre-aneurismal aorta near the aortic arch in pre-aneurysmal aorta may explain the aneurysm formation at the aortic arch. We found that high endothelial cell action potential (ECAP) correlates with the recirculation regions, which might indicate possible thrombus development. The promising image-based fluid-structure interaction model, accompanied with an in vitro experimental study, has the potential to be used for performing virtual implantation of newly developed stent graft for treatment of TAA.
Source Title: JOURNAL OF APPLIED FLUID MECHANICS
URI: https://scholarbank.nus.edu.sg/handle/10635/207076
ISSN: 17353572
17353645
DOI: 10.29252/jafm.12.06.29769
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