Please use this identifier to cite or link to this item: https://doi.org/10.3389/fonc.2019.00048
Title: Signal transducer and activator of transcription (STATs) proteins in cancer and inflammation: Functions and therapeutic implication
Authors: Loh, C.-Y.
Arya, A.
Naema, A.F.
Wong, W.F.
Sethi, G. 
Looi, C.Y.
Keywords: Cancer
Inflammation
STAT transcription factors
STAT3
Therapeutic implication
Issue Date: 2019
Publisher: Frontiers Media S.A.
Citation: Loh, C.-Y., Arya, A., Naema, A.F., Wong, W.F., Sethi, G., Looi, C.Y. (2019). Signal transducer and activator of transcription (STATs) proteins in cancer and inflammation: Functions and therapeutic implication. Frontiers in Oncology 9 (FEB) : 48. ScholarBank@NUS Repository. https://doi.org/10.3389/fonc.2019.00048
Rights: Attribution 4.0 International
Abstract: Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways. Each family member plays unique functions in signal transduction and crucial in mediating cellular responses to different kind of cytokines. STAT family members notably STAT3 and STAT5 have been involved in cancer progression whereas STAT1 plays opposite role by suppressing tumor growth. Persistent STAT3/5 activation is known to promote chronic inflammation, which increases susceptibility of healthy cells to carcinogenesis. Here, we review the role of STATs in cancers and inflammation while discussing current therapeutic implications in different cancers and test models, especially the delivery of STAT3/5 targeting siRNA using nanoparticulate delivery system. Copyright © 2019 Loh, Arya, Naema, Wong, Sethi and Looi.
Source Title: Frontiers in Oncology
URI: https://scholarbank.nus.edu.sg/handle/10635/206406
ISSN: 2234-943X
DOI: 10.3389/fonc.2019.00048
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3389_fonc_2019_00048.pdf1.51 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons