ROS and the DNA damage response in cancer
Srinivas, U.S. Tan, B.W.Q. Vellayappan, B.A. Jeyasekharan, A.D.
Tan, B.W.Q.
Vellayappan, B.A.
Citations
Altmetric:
Alternative Title
Abstract
Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-containing molecules that can induce DNA damage and affect the DNA damage response (DDR). There is unequivocal pre-clinical and clinical evidence that ROS influence the genotoxic stress caused by chemotherapeutics agents and ionizing radiation. Recent studies have provided mechanistic insight into how ROS can also influence the cellular response to DNA damage caused by genotoxic therapy, especially in the context of Double Strand Breaks (DSBs). This has led to the clinical evaluation of agents modulating ROS in combination with genotoxic therapy for cancer, with mixed success so far. These studies point to context dependent outcomes with ROS modulator combinations with Chemotherapy and radiotherapy, indicating a need for additional pre-clinical research in the field. In this review, we discuss the current knowledge on the effect of ROS in the DNA damage response, and its clinical relevance. © 2019 The Authors
Keywords
Chemotherapy, DDR, DNA damage response, Radiotherapy, Reactive Oxygen Species, ROS
Source Title
Redox Biology
Publisher
Elsevier B.V.
Series/Report No.
Collections
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Date
2019
DOI
10.1016/j.redox.2018.101084
Type
Review