Integrated metabolomics and metallomics analyses in acute coronary syndrome patients

Abstract

Acute coronary syndrome (ACS) is the leading cause of morbidity and mortality. Accurate risk prediction in ACS patients is critically important for helping clinicians make therapeutic decisions, such as recommending a more aggressive intervention and intensive follow-up. However, risk stratification in ACS patients remains challenging, and the identification of novel predictors is necessary for improving the prognostic prediction in ACS patients. We employed metallomics and untargeted metabolomics approaches to discover new biomarkers from the plasma samples of 20 ACS patients and 20 non-ACS patients. We identified metabolic changes related to lysophosphatidylcholines, caffeine, glycolysis, tryptophan and sphingomyelin metabolism (p value <0.05) that were perturbed in the ACS patients. Moreover, circulating metal elements, including Mg, Ca, K, Zn, Ni, Ga and In (p value <0.05), were altered in the ACS patients versus the controls. These changes suggest possible changes in cell membrane permeability and rigidity in ACS patients.