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Title: Association of leukocyte telomere length with obesity-related traits in Asian children with early-onset obesity
Authors: Ooi, Delicia Shu Qin
Dorajoo, Rajkumar
Gurung, Resham L
Dehghan, Roghayeh
Lim, Yvonne Yijuan
Ho, Cindy Wei Li
Tay, Veronica
Karuppiah, Vijaya
Loke, Kah Yin
Lim, Su Chi 
Liu, Jian-Jun
Sng, Andrew Anjian 
Lee, Yung Seng 
Keywords: Science & Technology
Life Sciences & Biomedicine
leukocyte telomere length
Issue Date: 26-Jan-2021
Publisher: WILEY
Citation: Ooi, Delicia Shu Qin, Dorajoo, Rajkumar, Gurung, Resham L, Dehghan, Roghayeh, Lim, Yvonne Yijuan, Ho, Cindy Wei Li, Tay, Veronica, Karuppiah, Vijaya, Loke, Kah Yin, Lim, Su Chi, Liu, Jian-Jun, Sng, Andrew Anjian, Lee, Yung Seng (2021-01-26). Association of leukocyte telomere length with obesity-related traits in Asian children with early-onset obesity. PEDIATRIC OBESITY 16 (8). ScholarBank@NUS Repository.
Abstract: Background: Leukocyte telomere length (LTL) is associated with obesity and obesity-related traits, and there are ethnic-specific determinants of LTL. Objective: To evaluate LTL associations with obesity and metabolic parameters in Asian children with early-onset obesity. Methods: Genomic DNA was extracted from peripheral blood leukocytes of a cohort of children with (N = 371) and without obesity (N = 23), and LTL was measured using quantitative PCR (qPCR). Blood plasma was used for metabolic phenotyping. Statistical analysis was performed using SPSS and STATA. Results: Children with obesity had shorter LTL (coefficient = −0.683, PAdj = 1.24 × 10−3) as compared to children who were lean. LTL was found to be associated with waist circumference (coefficient = −0.326, PAdj = 0.044) and skin-fold measures (coefficient between 0.267 and 0.301, PAdj between 4.27 × 10−4 and 7.06 × 10−7) in children with obesity. However, no significant associations were observed between LTL and metabolic parameters, and between LTL and inflammatory cytokines. LTL also did not significantly mediate the risk of non-alcoholic fatty liver disease (NAFLD) in children with obesity. Conclusions: We showed for the first time that Asian children with severe obesity had shorter LTL, and the shortening of LTL was associated with other adiposity measures including waist circumference and skin-fold measurements.
ISSN: 20476310
DOI: 10.1111/ijpo.12771
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