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https://doi.org/10.1038/s41380-020-0719-3
Title: | Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci | Authors: | de las Fuentes, Lisa Sung, Yun Ju Noordam, Raymond Winkler, Thomas Feitosa, Mary F Schwander, Karen Bentley, Amy R Brown, Michael R Guo, Xiuqing Manning, Alisa Chasman, Daniel I Aschard, Hugues Bartz, Traci M Bielak, Lawrence F Campbell, Archie Cheng, Ching-Yu Dorajoo, Rajkumar Hartwig, Fernando P Horimoto, ARVR Li, Changwei Li-Gao, Ruifang Liu, Yongmei Marten, Jonathan Musani, Solomon K Ntalla, Ioanna Rankinen, Tuomo Richard, Melissa Sim, Xueling Smith, Albert V Tajuddin, Salman M Tayo, Bamidele O Vojinovic, Dina Warren, Helen R Xuan, Deng Alver, Maris Boissel, Mathilde Chai, Jin-Fang Chen, Xu Christensen, Kaare Divers, Jasmin Evangelou, Evangelos Gao, Chuan Girotto, Giorgia Harris, Sarah E He, Meian Hsu, Fang-Chi Kuehnel, Brigitte Laguzzi, Federica Li, Xiaoyin Lyytikainen, Leo-Pekka Nolte, Ilja M Poveda, Alaitz Rauramaa, Rainer Riaz, Muhammad Rueedi, Rico Shu, Xiao-ou Snieder, Harold Sofer, Tamar Takeuchi, Fumihiko Verweij, Niek Ware, Erin B Weiss, Stefan Yanek, Lisa R Amin, Najaf Arking, Dan E Arnett, Donna K Bergmann, Sven Boerwinkle, Eric Brody, Jennifer A Broeckel, Ulrich Brumat, Marco Burke, Gregory Cabrera, Claudia P Canouil, Mickael Chee, Miao Li Chen, Yii-Der Ida Cocca, Massimiliano Connell, John de Silva, H Janaka de Vries, Paul S Eiriksdottir, Gudny Faul, Jessica D Fisher, Virginia Forrester, Terrence Fox, Ervin F Friedlander, Yechiel Gao, He Gigante, Bruna Giulianini, Franco Gu, Chi Charles Gu, Dongfeng Harris, Tamara B He, Jiang Heikkinen, Sami Heng, Chew-Kiat Hunt, Steven Ikram, M Arfan Irvin, Marguerite R Kahonen, Mika Kavousi, Maryam Khor, Chiea Chuen Kilpelainen, Tuomas O Koh, Woon-Puay Komulainen, Pirjo Kraja, Aldi T Krieger, JE Langefeld, Carl D Li, Yize Liang, Jingjing Liewald, David CM Liu, Ching-Ti Liu, Jianjun Lohman, Kurt K Magi, Reedik McKenzie, Colin A Meitinger, Thomas Metspalu, Andres Milaneschi, Yuri Milani, Lili Mook-Kanamori, Dennis O Nalls, Mike A Nelson, Christopher P Norris, Jill M O'Connell, Jeff Ogunniyi, Adesola Padmanabhan, Sandosh Palmer, Nicholette D Pedersen, Nancy L Perls, Thomas Peters, Annette Petersmann, Astrid Peyser, Patricia A Polasek, Ozren Porteous, David J Raffel, Leslie J Rice, Treva K Rotter, Jerome I Rudan, Igor Rueda-Ochoa, Oscar-Leonel Sabanayagam, Charumathi Salako, Babatunde L Schreiner, Pamela J Shikany, James M Sidney, Stephen S Sims, Mario Sitlani, Colleen M Smith, Jennifer A Starr, John M Strauch, Konstantin Swertz, Morris A Teumer, Alexander Tham, Yih Chung Uitterlinden, Andre G Vaidya, Dhananjay van der Ende, M Yldau Waldenberger, Melanie Wang, Lihua Wang, Ya-Xing Wei, Wen-Bin Weir, David R Wen, Wanqing Yao, Jie Yu, Bing Yu, Caizheng Yuan, Jian-Min Zhao, Wei Zonderman, Alan B Becker, Diane M Bowden, Donald W Deary, Ian J Doerr, Marcus Esko, Tonu Freedman, Barry I Froguel, Philippe Gasparini, Paolo Gieger, Christian Jonas, Jost Bruno Kammerer, Candace M Kato, Norihiro Lakka, Timo A Leander, Karin Lehtimaki, Terho Magnusson, Patrik KE Marques-Vidal, Pedro Penninx, Brenda WJH Samani, Nilesh J van der Harst, Pim Wagenknecht, Lynne E Wu, Tangchun Zheng, Wei Zhu, Xiaofeng Bouchard, Claude Cooper, Richard S Correa, Adolfo Evans, Michele K Gudnason, Vilmundur Hayward, Caroline Horta, Bernardo L Kelly, Tanika N Kritchevsky, Stephen B Levy, Daniel Palmas, Walter R Pereira, AC Province, Michael M Psaty, Bruce M Ridker, Paul M Rotimi, Charles N Tai, E Shyong van Dam, Rob M van Duijn, Cornelia M Wong, Tien Yin Rice, Kenneth Gauderman, W James Morrison, Alanna C North, Kari E Kardia, Sharon LR Caulfield, Mark J Elliott, Paul Munroe, Patricia B Franks, Paul W Rao, Dabeeru C Fornage, Myriam |
Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Neurosciences Psychiatry Neurosciences & Neurology CORONARY-HEART-DISEASE SOCIOECONOMIC-STATUS RISK-FACTORS CARDIOVASCULAR-DISEASE ESSENTIAL-HYPERTENSION C825T POLYMORPHISM SOCIAL-CLASS ASSOCIATION EXPRESSION VARIANTS |
Issue Date: | 5-May-2020 | Publisher: | NATURE PUBLISHING GROUP | Citation: | de las Fuentes, Lisa, Sung, Yun Ju, Noordam, Raymond, Winkler, Thomas, Feitosa, Mary F, Schwander, Karen, Bentley, Amy R, Brown, Michael R, Guo, Xiuqing, Manning, Alisa, Chasman, Daniel I, Aschard, Hugues, Bartz, Traci M, Bielak, Lawrence F, Campbell, Archie, Cheng, Ching-Yu, Dorajoo, Rajkumar, Hartwig, Fernando P, Horimoto, ARVR, Li, Changwei, Li-Gao, Ruifang, Liu, Yongmei, Marten, Jonathan, Musani, Solomon K, Ntalla, Ioanna, Rankinen, Tuomo, Richard, Melissa, Sim, Xueling, Smith, Albert V, Tajuddin, Salman M, Tayo, Bamidele O, Vojinovic, Dina, Warren, Helen R, Xuan, Deng, Alver, Maris, Boissel, Mathilde, Chai, Jin-Fang, Chen, Xu, Christensen, Kaare, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Girotto, Giorgia, Harris, Sarah E, He, Meian, Hsu, Fang-Chi, Kuehnel, Brigitte, Laguzzi, Federica, Li, Xiaoyin, Lyytikainen, Leo-Pekka, Nolte, Ilja M, Poveda, Alaitz, Rauramaa, Rainer, Riaz, Muhammad, Rueedi, Rico, Shu, Xiao-ou, Snieder, Harold, Sofer, Tamar, Takeuchi, Fumihiko, Verweij, Niek, Ware, Erin B, Weiss, Stefan, Yanek, Lisa R, Amin, Najaf, Arking, Dan E, Arnett, Donna K, Bergmann, Sven, Boerwinkle, Eric, Brody, Jennifer A, Broeckel, Ulrich, Brumat, Marco, Burke, Gregory, Cabrera, Claudia P, Canouil, Mickael, Chee, Miao Li, Chen, Yii-Der Ida, Cocca, Massimiliano, Connell, John, de Silva, H Janaka, de Vries, Paul S, Eiriksdottir, Gudny, Faul, Jessica D, Fisher, Virginia, Forrester, Terrence, Fox, Ervin F, Friedlander, Yechiel, Gao, He, Gigante, Bruna, Giulianini, Franco, Gu, Chi Charles, Gu, Dongfeng, Harris, Tamara B, He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hunt, Steven, Ikram, M Arfan, Irvin, Marguerite R, Kahonen, Mika, Kavousi, Maryam, Khor, Chiea Chuen, Kilpelainen, Tuomas O, Koh, Woon-Puay, Komulainen, Pirjo, Kraja, Aldi T, Krieger, JE, Langefeld, Carl D, Li, Yize, Liang, Jingjing, Liewald, David CM, Liu, Ching-Ti, Liu, Jianjun, Lohman, Kurt K, Magi, Reedik, McKenzie, Colin A, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Milani, Lili, Mook-Kanamori, Dennis O, Nalls, Mike A, Nelson, Christopher P, Norris, Jill M, O'Connell, Jeff, Ogunniyi, Adesola, Padmanabhan, Sandosh, Palmer, Nicholette D, Pedersen, Nancy L, Perls, Thomas, Peters, Annette, Petersmann, Astrid, Peyser, Patricia A, Polasek, Ozren, Porteous, David J, Raffel, Leslie J, Rice, Treva K, Rotter, Jerome I, Rudan, Igor, Rueda-Ochoa, Oscar-Leonel, Sabanayagam, Charumathi, Salako, Babatunde L, Schreiner, Pamela J, Shikany, James M, Sidney, Stephen S, Sims, Mario, Sitlani, Colleen M, Smith, Jennifer A, Starr, John M, Strauch, Konstantin, Swertz, Morris A, Teumer, Alexander, Tham, Yih Chung, Uitterlinden, Andre G, Vaidya, Dhananjay, van der Ende, M Yldau, Waldenberger, Melanie, Wang, Lihua, Wang, Ya-Xing, Wei, Wen-Bin, Weir, David R, Wen, Wanqing, Yao, Jie, Yu, Bing, Yu, Caizheng, Yuan, Jian-Min, Zhao, Wei, Zonderman, Alan B, Becker, Diane M, Bowden, Donald W, Deary, Ian J, Doerr, Marcus, Esko, Tonu, Freedman, Barry I, Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Jonas, Jost Bruno, Kammerer, Candace M, Kato, Norihiro, Lakka, Timo A, Leander, Karin, Lehtimaki, Terho, Magnusson, Patrik KE, Marques-Vidal, Pedro, Penninx, Brenda WJH, Samani, Nilesh J, van der Harst, Pim, Wagenknecht, Lynne E, Wu, Tangchun, Zheng, Wei, Zhu, Xiaofeng, Bouchard, Claude, Cooper, Richard S, Correa, Adolfo, Evans, Michele K, Gudnason, Vilmundur, Hayward, Caroline, Horta, Bernardo L, Kelly, Tanika N, Kritchevsky, Stephen B, Levy, Daniel, Palmas, Walter R, Pereira, AC, Province, Michael M, Psaty, Bruce M, Ridker, Paul M, Rotimi, Charles N, Tai, E Shyong, van Dam, Rob M, van Duijn, Cornelia M, Wong, Tien Yin, Rice, Kenneth, Gauderman, W James, Morrison, Alanna C, North, Kari E, Kardia, Sharon LR, Caulfield, Mark J, Elliott, Paul, Munroe, Patricia B, Franks, Paul W, Rao, Dabeeru C, Fornage, Myriam (2020-05-05). Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. MOLECULAR PSYCHIATRY 26 (6). ScholarBank@NUS Repository. https://doi.org/10.1038/s41380-020-0719-3 | Abstract: | Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 × 10-8). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2 and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP. | Source Title: | MOLECULAR PSYCHIATRY | URI: | https://scholarbank.nus.edu.sg/handle/10635/206003 | ISSN: | 13594184 14765578 |
DOI: | 10.1038/s41380-020-0719-3 |
Appears in Collections: | Elements Staff Publications |
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