Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.carrev.2018.11.004
Title: Clinical Outcomes One Year and Beyond After Combination Sirolimus-Eluting Endothelial Progenitor Cell Capture Stenting During Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction
Authors: Sim, HW
Thong, EH
Tan, HC 
Low, AF 
Lee, CH 
Chan, MY 
Tay, EL 
Loh, PH 
Chan, KH 
Loh, JP 
Keywords: Aged
Antibodies, Monoclonal
Antigens, CD34
Cardiovascular Agents
Cell Adhesion
Coronary Artery Disease
Drug-Eluting Stents
Endothelial Progenitor Cells
Female
Humans
Male
Middle Aged
Percutaneous Coronary Intervention
Prosthesis Design
Registries
ST Elevation Myocardial Infarction
Sirolimus
Time Factors
Treatment Outcome
Issue Date: 1-Sep-2019
Publisher: Elsevier BV
Citation: Sim, HW, Thong, EH, Tan, HC, Low, AF, Lee, CH, Chan, MY, Tay, EL, Loh, PH, Chan, KH, Loh, JP (2019-09-01). Clinical Outcomes One Year and Beyond After Combination Sirolimus-Eluting Endothelial Progenitor Cell Capture Stenting During Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction. Cardiovascular Revascularization Medicine 20 (9) : 739-743. ScholarBank@NUS Repository. https://doi.org/10.1016/j.carrev.2018.11.004
Abstract: Background/purpose: Primary percutaneous coronary intervention (PCI) during acute ST-segment elevation myocardial infarction (STEMI) represents a thrombotic milieu and is associated with delayed healing after stenting. The pro-healing combination sirolimus eluting endothelial progenitor cell (EPC) capture stents encourage early endothelialization after stenting and may be beneficial in the STEMI population. We aim to evaluate the clinical outcomes one year and beyond for patients with STEMI who received the combination sirolimus eluting EPC capture stents during primary PCI. Methods/material: All STEMI patients implanted with combination sirolimus eluting EPC capture stents during primary PCI from November 2013 to December 2016 were enrolled. The primary outcome was target lesion failure (TLF) at in-hospital, one-month, one-year and beyond one year. Results: A total of 260 consecutive STEMI patients (283 lesions) were implanted with 313 combination sirolimus eluting EPC capture stents during primary PCI. Mean age was 56.1 ± 11.2 years and 88.8% were male. One in ten patients (10.9%) had cardiogenic shock on presentation, 7.3% needed mechanical ventilation and 7.7% had intra-aortic balloon pump inserted. A total of 97.9% of lesions achieve final TIMI 3 flow. Device success was seen in all patients. At extended follow up period (median 23.4 months), the clinical outcomes were TLF 8.8%, major adverse cardiovascular events 10.8%, cardiac mortality 4.2%, target vessel myocardial infarction 3.4%, target lesion revascularization 3.8%, and definite stent thrombosis 1.9%. Conclusions: This study demonstrated acceptable clinical outcomes for an all-comers STEMI patients undergoing primary PCI with the use of combination sirolimus eluting EPC cell capture stents.
Source Title: Cardiovascular Revascularization Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/205883
ISSN: 15538389
18780938
DOI: 10.1016/j.carrev.2018.11.004
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Clinical Outcomes One Year and Beyond After Combination Sirolimus-Eluting Endothelial Progenitor Cell Capture Stenting During Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction.pdfPublished version312.65 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

1
checked on Jun 22, 2022

Page view(s)

79
checked on Jun 23, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.