Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12955-020-01640-5
Title: Impact of COVID-19 on health-related quality of life in patients with cardiovascular disease: a multi-ethnic Asian study
Authors: Lim, Shir Lynn 
Woo, Kai Lee
Lim, Eleanor
Ng, Faclin
Chan, Mark Y 
Gandhi, Mihir
Keywords: COVID-19
Health-related quality of life
Cardiovascular
EQ-5D
Psychological health
Issue Date: 14-Dec-2020
Publisher: BMC
Citation: Lim, Shir Lynn, Woo, Kai Lee, Lim, Eleanor, Ng, Faclin, Chan, Mark Y, Gandhi, Mihir (2020-12-14). Impact of COVID-19 on health-related quality of life in patients with cardiovascular disease: a multi-ethnic Asian study. HEALTH AND QUALITY OF LIFE OUTCOMES 18 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12955-020-01640-5
Abstract: Background: Little is known about the impact of the global coronavirus disease-2019 (COVID-19) pandemic on patients with cardiovascular disease (CVD), the biggest global killer and major risk factor for severe COVID-19 infections. We aim to explore the indirect consequences of COVID-19 on health-related quality of life (HRQoL) of patients with CVD. Methods: Eighty-one adult outpatients with CVD were assessed using the EQ-5D, a generic health status instrument with five dimensions (mobility, self-care, usual activities, pain/discomfort, anxiety/depression), before and during the pandemic. Changes in the EQ-5D dimensional responses were compared categorically as well as using the dimension-specific sum-score (range 1–3, with a higher score indicating worse health). The responses and sum-score were compared using the exact test of symmetry and the paired t-test, respectively. Results: These patients [mean age (SD) 59.8 (10.5); 92.6% males; 56% New York Heart Association (NYHA) functional class I] had coronary artery disease (69%), heart failure (28%), or arrhythmias (15%). None experienced change in NYHA class between assessments. About 30% and 38% of patients reported problems with at least one of the EQ-5D dimensions pre-pandemic and during the pandemic, respectively. The highest increase in health problems was reported for anxiety/depression (12.5% pre-pandemic vs 23.5% during pandemic; p = 0.035) with mean domain-specific score from 1.12 (SD 0.33) to 1.25 (SD 0.46) (standardized effect size = 0.373, p = 0.012). There was no meaningful change in other dimensions as well as overall HRQoL. Conclusion: The COVID-19 pandemic is associated with a significant worsening of the mental health of patients with CVD.
Source Title: HEALTH AND QUALITY OF LIFE OUTCOMES
URI: https://scholarbank.nus.edu.sg/handle/10635/205820
ISSN: 14777525
DOI: 10.1186/s12955-020-01640-5
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